Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole

J. Mosquera; P. A. Warn; J. L. Rodriguez-Tudela; D. W. Denning

doi:10.1093/jac/48.4.583

Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole

J. Mosquera, P. A. Warn, J. L. Rodriguez-Tudela, D. W. Denning

Research output: Contribution to journal › Article › peer-review

Abstract

The activities of amphotericin B and itraconazole were studied in a temporarily neutropenic murine model of disseminated Absidia corymbifera infection, caused by two different strains. Amphotericin B MICs were 0.25 mg/L for both strains and itraconazole MICs were 1 and 2 mg/L. Amphotericin B was effective in vivo with both isolates. Itraconazole was less effective.

Original language	English
Pages (from-to)	583-586
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	48
Issue number	4
DOIs	https://doi.org/10.1093/jac/48.4.583
Publication status	Published - 2001

Keywords

classification: Absidia
therapeutic use: Amphotericin B
Animal
therapeutic use: Antifungal Agents
Disease Models, Animal
Human
therapeutic use: Itraconazole
Male
Mice
methods: Microbial Sensitivity Tests
drug therapy: Mucormycosis
Support, Non-U.S. Gov't

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10.1093/jac/48.4.583

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title = "Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole",

abstract = "The activities of amphotericin B and itraconazole were studied in a temporarily neutropenic murine model of disseminated Absidia corymbifera infection, caused by two different strains. Amphotericin B MICs were 0.25 mg/L for both strains and itraconazole MICs were 1 and 2 mg/L. Amphotericin B was effective in vivo with both isolates. Itraconazole was less effective.",

keywords = "classification: Absidia, therapeutic use: Amphotericin B, Animal, therapeutic use: Antifungal Agents, Disease Models, Animal, Human, therapeutic use: Itraconazole, Male, Mice, methods: Microbial Sensitivity Tests, drug therapy: Mucormycosis, Support, Non-U.S. Gov't",

author = "J. Mosquera and Warn, {P. A.} and Rodriguez-Tudela, {J. L.} and Denning, {D. W.}",

year = "2001",

doi = "10.1093/jac/48.4.583",

language = "English",

volume = "48",

pages = "583--586",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

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}

TY - JOUR

T1 - Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole

AU - Mosquera, J.

AU - Warn, P. A.

AU - Rodriguez-Tudela, J. L.

AU - Denning, D. W.

PY - 2001

Y1 - 2001

N2 - The activities of amphotericin B and itraconazole were studied in a temporarily neutropenic murine model of disseminated Absidia corymbifera infection, caused by two different strains. Amphotericin B MICs were 0.25 mg/L for both strains and itraconazole MICs were 1 and 2 mg/L. Amphotericin B was effective in vivo with both isolates. Itraconazole was less effective.

AB - The activities of amphotericin B and itraconazole were studied in a temporarily neutropenic murine model of disseminated Absidia corymbifera infection, caused by two different strains. Amphotericin B MICs were 0.25 mg/L for both strains and itraconazole MICs were 1 and 2 mg/L. Amphotericin B was effective in vivo with both isolates. Itraconazole was less effective.

KW - classification: Absidia

KW - therapeutic use: Amphotericin B

KW - Animal

KW - therapeutic use: Antifungal Agents

KW - Disease Models, Animal

KW - Human

KW - therapeutic use: Itraconazole

KW - Male

KW - Mice

KW - methods: Microbial Sensitivity Tests

KW - drug therapy: Mucormycosis

KW - Support, Non-U.S. Gov't

U2 - 10.1093/jac/48.4.583

DO - 10.1093/jac/48.4.583

M3 - Article

C2 - 11581243

SN - 0305-7453

VL - 48

SP - 583

EP - 586

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 4

ER -

Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole

Abstract

Keywords

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