Treatment options for infections caused by carbapenem-resistant gram-negative bacteria

Chris Kosmidis, Garyphalia Poulakou, Antonios Markogiannakis, George L. Daikos

Research output: Contribution to journalArticlepeer-review


Carbapenem-resistant Gram-negative bacteria have spread worldwide and constitute a serious public health problem. These organisms are frequently resistant to multiple classes of antimicrobials, limiting our therapeutic options. Agents with potential activity against these multi-drug-resistant bacteria include sulbactam, colistin, tigecycline, aminoglycosides, fosfomycin and, under certain conditions, β-lactams. Clinical experience on the value of each of these agents is still limited. However, in the absence of solid data, various combinations of antibiotics are frequently employed for the treatment of severe infections caused by carbapenem-resistant bacteria.

Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalEuropean Infectious Disease
Issue number1
Publication statusPublished - 1 Mar 2012


  • Acinetobacter
  • Carbapenem-resistant
  • Enterobacteriaceae
  • Epidemiology
  • Multi-drug resistance
  • Nosocomial infections
  • Pseudomonas
  • Resistance mechanisms
  • Treatment


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