Trends and outcome from radical therapy for primary non-metastatic prostate cancer in a UK population

D C Greenberg; A Lophatananon; K A Wright; K R Muir; V J Gnanapragasam

doi:10.1371/journal.pone.0119494

Trends and outcome from radical therapy for primary non-metastatic prostate cancer in a UK population

D C Greenberg, A Lophatananon, K A Wright, K R Muir, V J Gnanapragasam

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Increasing proportions of men diagnosed with prostate cancer in the UK are presenting with non-metastatic disease. We investigated how treatment trends in this demographic have changed. PATIENT AND METHODS: Non-metastatic cancers diagnosed from 2000-2010 in the UK Anglian Cancer network stratified by age and risk group were analysed [n = 10,365]. Radiotherapy [RT] and prostatectomy [RP] cancer specific survival [CSS] were further compared [n = 4755]. RESULTS: Over the decade we observed a fall in uptake of primary androgen deprivation therapy but a rise in conservative management [CM] and radical therapy [p/= 70y. In multivariate analysis of radically treated men both high-risk disease [HR 8.0 [2.9-22.2], p

Original language	English
Journal	PLoS ONE
Volume	10
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0119494
Publication status	Published - 2015

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abstract = "BACKGROUND: Increasing proportions of men diagnosed with prostate cancer in the UK are presenting with non-metastatic disease. We investigated how treatment trends in this demographic have changed. PATIENT AND METHODS: Non-metastatic cancers diagnosed from 2000-2010 in the UK Anglian Cancer network stratified by age and risk group were analysed [n = 10,365]. Radiotherapy [RT] and prostatectomy [RP] cancer specific survival [CSS] were further compared [n = 4755]. RESULTS: Over the decade we observed a fall in uptake of primary androgen deprivation therapy but a rise in conservative management [CM] and radical therapy [p/= 70y. In multivariate analysis of radically treated men both high-risk disease [HR 8.0 [2.9-22.2], p",

author = "Greenberg, {D C} and A Lophatananon and Wright, {K A} and Muir, {K R} and Gnanapragasam, {V J}",

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T1 - Trends and outcome from radical therapy for primary non-metastatic prostate cancer in a UK population

AU - Greenberg, D C

AU - Lophatananon, A

AU - Wright, K A

AU - Muir, K R

AU - Gnanapragasam, V J

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PY - 2015

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N2 - BACKGROUND: Increasing proportions of men diagnosed with prostate cancer in the UK are presenting with non-metastatic disease. We investigated how treatment trends in this demographic have changed. PATIENT AND METHODS: Non-metastatic cancers diagnosed from 2000-2010 in the UK Anglian Cancer network stratified by age and risk group were analysed [n = 10,365]. Radiotherapy [RT] and prostatectomy [RP] cancer specific survival [CSS] were further compared [n = 4755]. RESULTS: Over the decade we observed a fall in uptake of primary androgen deprivation therapy but a rise in conservative management [CM] and radical therapy [p/= 70y. In multivariate analysis of radically treated men both high-risk disease [HR 8.0 [2.9-22.2], p

AB - BACKGROUND: Increasing proportions of men diagnosed with prostate cancer in the UK are presenting with non-metastatic disease. We investigated how treatment trends in this demographic have changed. PATIENT AND METHODS: Non-metastatic cancers diagnosed from 2000-2010 in the UK Anglian Cancer network stratified by age and risk group were analysed [n = 10,365]. Radiotherapy [RT] and prostatectomy [RP] cancer specific survival [CSS] were further compared [n = 4755]. RESULTS: Over the decade we observed a fall in uptake of primary androgen deprivation therapy but a rise in conservative management [CM] and radical therapy [p/= 70y. In multivariate analysis of radically treated men both high-risk disease [HR 8.0 [2.9-22.2], p

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Trends and outcome from radical therapy for primary non-metastatic prostate cancer in a UK population

Abstract

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