Trichuris muris research revisited: A journey through time

Rebecca J M Hurst, Kathryn J. Else

Research output: Contribution to journalArticlepeer-review

Abstract

The mouse whipworm Trichuris muris has long been used as a tractable model of human Trichuriasis. Here we look back at the history of T. muris research; from the definition of the species and determination of its life cycle, through to the complex immune responses that we study today. We highlight the key research papers that have developed our understanding of immune responses to this parasite, and reflect on how original concepts have been transformed, as our knowledge of immunology has grown. Although we have a good understanding of host-parasite interactions in the context of the underlying cellular immunology, there are still many aspects of the biology of the Trichuris parasite that remain undefined. We predict that advances in parasite biology will be key in the future development of new and improved treatments for Trichuriasis. Copyright © 2013 Cambridge University Press.
Original languageEnglish
Pages (from-to)1325-1339
Number of pages14
JournalParasitology
Volume140
Issue number11
DOIs
Publication statusPublished - Sept 2013

Keywords

  • helminth
  • mouse
  • nematode
  • parasite
  • Trichuris muris

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