Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations

J. V. Patel; M. J. Caslake; A. Vyas; J. K. Cruickshank; D. Prabhakaran; D. Bhatnagar; K. S. Reddy; G. Y H Lip; M. I. Mackness; E. A. Hughes; P. N. Durrington

doi:10.1016/j.atherosclerosis.2009.10.010

Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations

J. V. Patel, M. J. Caslake, A. Vyas, J. K. Cruickshank, D. Prabhakaran, D. Bhatnagar, K. S. Reddy, G. Y H Lip, M. I. Mackness, E. A. Hughes, P. N. Durrington

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Coronary heart disease (CHD) is exceptionally prevalent amongst globally dispersed migrant groups originating from the Indian subcontinent, but the contribution of dyslipidaemia to their increased risk remains poorly defined. Methods: Fasting lipids and lipoproteins, apolipoproteins (Apo), low density lipoprotein (LDL) diameter and oxidised LDL were measured amongst rural Indians in India (n=294) and their migrant contemporaries in the UK (n=242). The performance of qualitative and quantitative measures of lipid metabolism were compared in the discrimination of WHO defined metabolic risk and raised Framingham CHD risk scores (>15%) using Receiver Operating Characteristic (ROC) curves. Results: LDL diameter was correlated with triglycerides (R2=0.12, P

Original language	English
Pages (from-to)	579-584
Number of pages	5
Journal	Atherosclerosis
Volume	209
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2009.10.010
Publication status	Published - Apr 2010

Keywords

Apolipoproteins
HDL cholesterol
Oxidised LDL
Small dense LDL
South Asians

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2009.10.010

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Patel, J. V., Caslake, M. J., Vyas, A., Cruickshank, J. K., Prabhakaran, D., Bhatnagar, D., Reddy, K. S., Lip, G. Y. H., Mackness, M. I., Hughes, E. A., & Durrington, P. N. (2010). Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations. Atherosclerosis, 209(2), 579-584. https://doi.org/10.1016/j.atherosclerosis.2009.10.010

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title = "Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations",

abstract = "Introduction: Coronary heart disease (CHD) is exceptionally prevalent amongst globally dispersed migrant groups originating from the Indian subcontinent, but the contribution of dyslipidaemia to their increased risk remains poorly defined. Methods: Fasting lipids and lipoproteins, apolipoproteins (Apo), low density lipoprotein (LDL) diameter and oxidised LDL were measured amongst rural Indians in India (n=294) and their migrant contemporaries in the UK (n=242). The performance of qualitative and quantitative measures of lipid metabolism were compared in the discrimination of WHO defined metabolic risk and raised Framingham CHD risk scores (>15%) using Receiver Operating Characteristic (ROC) curves. Results: LDL diameter was correlated with triglycerides (R2=0.12, P",

keywords = "Apolipoproteins, HDL cholesterol, Oxidised LDL, Small dense LDL, South Asians",

author = "Patel, {J. V.} and Caslake, {M. J.} and A. Vyas and Cruickshank, {J. K.} and D. Prabhakaran and D. Bhatnagar and Reddy, {K. S.} and Lip, {G. Y H} and Mackness, {M. I.} and Hughes, {E. A.} and Durrington, {P. N.}",

note = ", British Heart Foundation, United Kingdom",

year = "2010",

month = apr,

doi = "10.1016/j.atherosclerosis.2009.10.010",

language = "English",

volume = "209",

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journal = "Atherosclerosis",

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Patel, JV, Caslake, MJ, Vyas, A, Cruickshank, JK, Prabhakaran, D, Bhatnagar, D, Reddy, KS, Lip, GYH, Mackness, MI, Hughes, EA & Durrington, PN 2010, 'Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations', Atherosclerosis, vol. 209, no. 2, pp. 579-584. https://doi.org/10.1016/j.atherosclerosis.2009.10.010

TY - JOUR

T1 - Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations

AU - Patel, J. V.

AU - Caslake, M. J.

AU - Vyas, A.

AU - Cruickshank, J. K.

AU - Prabhakaran, D.

AU - Bhatnagar, D.

AU - Reddy, K. S.

AU - Lip, G. Y H

AU - Mackness, M. I.

AU - Hughes, E. A.

AU - Durrington, P. N.

N1 - , British Heart Foundation, United Kingdom

PY - 2010/4

Y1 - 2010/4

N2 - Introduction: Coronary heart disease (CHD) is exceptionally prevalent amongst globally dispersed migrant groups originating from the Indian subcontinent, but the contribution of dyslipidaemia to their increased risk remains poorly defined. Methods: Fasting lipids and lipoproteins, apolipoproteins (Apo), low density lipoprotein (LDL) diameter and oxidised LDL were measured amongst rural Indians in India (n=294) and their migrant contemporaries in the UK (n=242). The performance of qualitative and quantitative measures of lipid metabolism were compared in the discrimination of WHO defined metabolic risk and raised Framingham CHD risk scores (>15%) using Receiver Operating Characteristic (ROC) curves. Results: LDL diameter was correlated with triglycerides (R2=0.12, P

AB - Introduction: Coronary heart disease (CHD) is exceptionally prevalent amongst globally dispersed migrant groups originating from the Indian subcontinent, but the contribution of dyslipidaemia to their increased risk remains poorly defined. Methods: Fasting lipids and lipoproteins, apolipoproteins (Apo), low density lipoprotein (LDL) diameter and oxidised LDL were measured amongst rural Indians in India (n=294) and their migrant contemporaries in the UK (n=242). The performance of qualitative and quantitative measures of lipid metabolism were compared in the discrimination of WHO defined metabolic risk and raised Framingham CHD risk scores (>15%) using Receiver Operating Characteristic (ROC) curves. Results: LDL diameter was correlated with triglycerides (R2=0.12, P

KW - Apolipoproteins

KW - HDL cholesterol

KW - Oxidised LDL

KW - Small dense LDL

KW - South Asians

U2 - 10.1016/j.atherosclerosis.2009.10.010

DO - 10.1016/j.atherosclerosis.2009.10.010

M3 - Article

C2 - 19922937

SN - 0021-9150

VL - 209

SP - 579

EP - 584

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations

Abstract

Keywords

UN SDGs

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