Tris-ureas as transmembrane anion transporters

Martina Olivari; Riccardo Montis; Stuart N. Berry; Louise E. Karagiannidis; Simon J. Coles; Peter N. Horton; Lucy K. Mapp; Philip A. Gale; Claudia Caltagirone

doi:10.1039/c6dt02046a

Tris-ureas as transmembrane anion transporters

Martina Olivari, Riccardo Montis, Stuart N. Berry, Louise E. Karagiannidis, Simon J. Coles, Peter N. Horton, Lucy K. Mapp, Philip A. Gale, Claudia Caltagirone

Research output: Contribution to journal › Article › peer-review

Abstract

Nine tris-urea receptors (L¹-L⁹) have been synthesised and shown to coordinate to a range of anionic guests both by ¹H NMR titration techniques and single crystal X-ray structural analysis. The compounds have been shown to be capable of mediating the exchange of chloride and nitrate and also chloride and bicarbonate across POPC or POPC:cholesterol 7:3 vesicle bilayer membranes at low transporter loadings. An interesting dependency of anion transport on the nature of the cation is evidence to suggest that a M⁺/Cl^- cotransport process may also contribute to the release of chloride from the vesicles.

Original language	English
Pages (from-to)	11892-11897
Number of pages	6
Journal	Dalton Transactions
Volume	45
Issue number	29
DOIs	https://doi.org/10.1039/c6dt02046a
Publication status	Published - 1 Jan 2016

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AU - Olivari, Martina

AU - Montis, Riccardo

AU - Berry, Stuart N.

AU - Karagiannidis, Louise E.

AU - Coles, Simon J.

AU - Horton, Peter N.

AU - Mapp, Lucy K.

AU - Gale, Philip A.

AU - Caltagirone, Claudia

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Tris-ureas as transmembrane anion transporters

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