Trophoblast-uterine interactions at implantation

John D. Aplin; Susan J. Kimber

doi:10.1186/1477-7827-2-48

Trophoblast-uterine interactions at implantation

Research output: Contribution to journal › Article › peer-review

Abstract

Implantation of the embryo in the uterus is a critical and complex event and its failure is widely considered an impediment to improved success in assisted reproduction. Depending on whether placentation is invasive or superficial (epitheliochorial), the embryo may interact transiently or undergo a prolonged adhesive interaction with the uterine epithelium. Numerous candidate interactions have been identified, and there is good progress on identifying gene networks required for early placentation. However no molecular mechanisms for the epithelial phase are yet firmly established in any species. It is noteworthy that gene ablation in mice has so far failed to identify obligatory initial molecular events. © 2004 Aplin and Kimber; licensee BioMed Central Ltd.

Original language	English
Article number	48
Journal	Reproductive Biology and Endocrinology
Volume	2
DOIs	https://doi.org/10.1186/1477-7827-2-48
Publication status	Published - 5 Jul 2004

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http://www.rbej.com/content/2/1/48

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abstract = "Implantation of the embryo in the uterus is a critical and complex event and its failure is widely considered an impediment to improved success in assisted reproduction. Depending on whether placentation is invasive or superficial (epitheliochorial), the embryo may interact transiently or undergo a prolonged adhesive interaction with the uterine epithelium. Numerous candidate interactions have been identified, and there is good progress on identifying gene networks required for early placentation. However no molecular mechanisms for the epithelial phase are yet firmly established in any species. It is noteworthy that gene ablation in mice has so far failed to identify obligatory initial molecular events. {\textcopyright} 2004 Aplin and Kimber; licensee BioMed Central Ltd.",

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AB - Implantation of the embryo in the uterus is a critical and complex event and its failure is widely considered an impediment to improved success in assisted reproduction. Depending on whether placentation is invasive or superficial (epitheliochorial), the embryo may interact transiently or undergo a prolonged adhesive interaction with the uterine epithelium. Numerous candidate interactions have been identified, and there is good progress on identifying gene networks required for early placentation. However no molecular mechanisms for the epithelial phase are yet firmly established in any species. It is noteworthy that gene ablation in mice has so far failed to identify obligatory initial molecular events. © 2004 Aplin and Kimber; licensee BioMed Central Ltd.

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Trophoblast-uterine interactions at implantation

Abstract

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