Tubular proteinuria and enzymuria following open heart surgery

John Blaikley, Peter Sutton, Mary Walter, Martha Lapsley, Anthony Norden, Wilf Pugsley, Robert Unwin

    Research output: Contribution to journalArticlepeer-review


    Objective: We investigated the effect of cardiac surgery on a marker of tubular damage, an enzyme called neutral endopeptidase (NEP), and on a marker of tubular function, retinol binding protein (RBP). Markers of tubular damage or function are useful in the early detection of acute renal failure and help identify the risk factors for this disease. We also examined if colloid interfered with NEP measurement. Design: A controlled prospective cohort study. Setting: A teaching cardio-thoracic unit in London, England. Patients and participants: Thirty-four patients underwent cardiac surgery. Eight patients waiting for cardiac surgery acted as controls. Interventions: Twenty-five patients had coronary artery bypass graft, four patients had valve replacements, one patient had a coronary artery bypass graft with a valve replacement and one patient had a left ventricular aneurysm repair. Measurements and Results: Neutral endopeptidase was measured in all the patients and controls. In separate subgroups RBP (n=5) and Gelofusine use (n=12) were recorded. Urine samples were collected pre-operatively, 3 h, 1 and 4 days post-operatively. NEP rose significantly (p
    Original languageEnglish
    Pages (from-to)1364-1367
    Number of pages3
    JournalIntensive care medicine
    Issue number8
    Publication statusPublished - 1 Aug 2003


    • Acute renal failure
    • Cardiopulmonary bypass
    • Neutral endopeptidase
    • Proteinuria


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