Research output per year
Research output per year
Steven Rossington, J. Hadfield, Steven D. Shnyder, Timothy Wallace, Kaye Williams
Research output: Contribution to journal › Article › peer-review
5,7-Dihydro-3,9,10,11-tetramethoxybenz[c,e]oxepin-4-ol 1, prepared from a dibenzyl ether precursor via Pd-catalysed intramolecular direct arylation, possesses broad-spectrum in vitro cytotoxicity towards various tumour cell lines, and induces vascular shutdown, necrosis and growth delay in tumour xenografts in mice at sub-toxic doses. The biological properties of 1 and related compounds can be attributed to their ability to inhibit microtubule assembly at the micromolar level, by binding reversibly to the same site of the tubulin αβ-heterodimer as colchicine 2 and the allocolchinol, N-acetylcolchinol 4.
Original language | English |
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Pages (from-to) | 1630-1642 |
Number of pages | 13 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 25 |
Issue number | 5 |
Early online date | 19 Jan 2017 |
DOIs | |
Publication status | Published - 1 Mar 2017 |
Research output: Contribution to journal › Article › peer-review