Tumor necrosis factor-alpha gene polymorphism and death due to acute cellular rejection in a subgroup of heart transplant recipients

M. Azzawi; P. S. Hasleton; D. M. Turner; N. Yonan; A. K. Deiraniya; P. J. Sinnott; I. V. Hutchinson

doi:10.1016/S0198-8859(00)00235-4

Tumor necrosis factor-alpha gene polymorphism and death due to acute cellular rejection in a subgroup of heart transplant recipients

M. Azzawi, P. S. Hasleton, D. M. Turner, N. Yonan, A. K. Deiraniya, P. J. Sinnott, I. V. Hutchinson

Research output: Contribution to journal › Article › peer-review

Abstract

Irreversible acute rejection of the transplanted heart usually has a fatal outcome. Predicting which recipients are most likely to reject might allow closer monitoring and modification of treatment protocols to prevent graft loss. Recipients genetically predisposed to produce more TNF-α are those who suffer the most acute rejection episodes. Here we show that TNF-α genotype is strongly associated with death due to acute cell-mediated heart transplant rejection (Chi-square = 28.57, p <0.0001). This subgroup of recipients should be given optimally tissue matched transplants and should be treated with the most effective immunosuppressive regimens. © American Society for Histocompatibility and Immunogenetics, 2001.

Original language	English
Pages (from-to)	140-142
Number of pages	2
Journal	Human immunology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/S0198-8859(00)00235-4
Publication status	Published - 2001

Keywords

Acute rejection
Heart transplantation
TNF-α gene polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0198-8859(00)00235-4

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title = "Tumor necrosis factor-alpha gene polymorphism and death due to acute cellular rejection in a subgroup of heart transplant recipients",

abstract = "Irreversible acute rejection of the transplanted heart usually has a fatal outcome. Predicting which recipients are most likely to reject might allow closer monitoring and modification of treatment protocols to prevent graft loss. Recipients genetically predisposed to produce more TNF-α are those who suffer the most acute rejection episodes. Here we show that TNF-α genotype is strongly associated with death due to acute cell-mediated heart transplant rejection (Chi-square = 28.57, p <0.0001). This subgroup of recipients should be given optimally tissue matched transplants and should be treated with the most effective immunosuppressive regimens. {\textcopyright} American Society for Histocompatibility and Immunogenetics, 2001.",

keywords = "Acute rejection, Heart transplantation, TNF-α gene polymorphism",

author = "M. Azzawi and Hasleton, \{P. S.\} and Turner, \{D. M.\} and N. Yonan and Deiraniya, \{A. K.\} and Sinnott, \{P. J.\} and Hutchinson, \{I. V.\}",

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TY - JOUR

T1 - Tumor necrosis factor-alpha gene polymorphism and death due to acute cellular rejection in a subgroup of heart transplant recipients

AU - Azzawi, M.

AU - Hasleton, P. S.

AU - Turner, D. M.

AU - Yonan, N.

AU - Deiraniya, A. K.

AU - Sinnott, P. J.

AU - Hutchinson, I. V.

PY - 2001

Y1 - 2001

N2 - Irreversible acute rejection of the transplanted heart usually has a fatal outcome. Predicting which recipients are most likely to reject might allow closer monitoring and modification of treatment protocols to prevent graft loss. Recipients genetically predisposed to produce more TNF-α are those who suffer the most acute rejection episodes. Here we show that TNF-α genotype is strongly associated with death due to acute cell-mediated heart transplant rejection (Chi-square = 28.57, p <0.0001). This subgroup of recipients should be given optimally tissue matched transplants and should be treated with the most effective immunosuppressive regimens. © American Society for Histocompatibility and Immunogenetics, 2001.

AB - Irreversible acute rejection of the transplanted heart usually has a fatal outcome. Predicting which recipients are most likely to reject might allow closer monitoring and modification of treatment protocols to prevent graft loss. Recipients genetically predisposed to produce more TNF-α are those who suffer the most acute rejection episodes. Here we show that TNF-α genotype is strongly associated with death due to acute cell-mediated heart transplant rejection (Chi-square = 28.57, p <0.0001). This subgroup of recipients should be given optimally tissue matched transplants and should be treated with the most effective immunosuppressive regimens. © American Society for Histocompatibility and Immunogenetics, 2001.

KW - Acute rejection

KW - Heart transplantation

KW - TNF-α gene polymorphism

UR - https://www.scopus.com/pages/publications/0035116792

U2 - 10.1016/S0198-8859(00)00235-4

DO - 10.1016/S0198-8859(00)00235-4

M3 - Article

SN - 0198-8859

VL - 62

SP - 140

EP - 142

JO - Human immunology

JF - Human immunology

IS - 2

ER -

Tumor necrosis factor-alpha gene polymorphism and death due to acute cellular rejection in a subgroup of heart transplant recipients

Abstract

Keywords

UN SDGs

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