Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis

E. Zeggini; W. Thomson; A. Alansari; W. Ollier; R. Donn; M. Abinun; M. Becker; A. Bell; A. Craft; E. Crawley; J. David; J. Gardener-Medwin; J. Griffin; A. Hall; M. Hall; A. Herrick; P. Hollingworth; L. Holt; S. Jones; G. Pountain; C. Ryder; T. Southwood; I. Stewart; P. Woo; S. Wyatt; H. Venning

Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis

E. Zeggini, W. Thomson, A. Alansari, W. Ollier, R. Donn, M. Abinun, M. Becker, A. Bell, A. Craft, E. Crawley, J. David, J. Gardener-Medwin, J. Griffin, A. Hall, M. Hall, A. Herrick, P. Hollingworth, L. Holt, S. Jones, G. PountainC. Ryder, T. Southwood, I. Stewart, P. Woo, S. Wyatt, H. Venning

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives. Juvenile idiopathic arthritis (JIA) is a complex polygenic disorder. The encouraging outcome of anti-tumour necrosis factor (TNF) treatment, as well as serological studies, has implicated TNF and its receptors (TNFRI and TNFRII, or TNFRSF1B) in the pathogenesis of JIA. The purpose of this study was to investigate the exon 6 TNFRII single nucleotide polymorphism (SNP) in a well-defined UK cohort of JIA patients, using case-control association analysis. Methods. A total of 435 patients, spanning seven JIA subgroups, and 261 healthy individuals were screened for the polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results. No significant differences were observed between the SNP allelic or genotypic frequencies of patients and controls, or between JIA subgroups. Conclusions. This TNFRII exon 6 SNP does not seem to be associated with susceptibility to JIA.

Original language	English
Pages (from-to)	462-465
Number of pages	3
Journal	Rheumatology
Volume	41
Issue number	4
Publication status	Published - 2002

Keywords

Complex genetic disease
Juvenile idiopathic arthritis
Single nucleotide polymorphism
Tumour necrosis factor receptor II

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Zeggini, E., Thomson, W., Alansari, A., Ollier, W., Donn, R., Abinun, M., Becker, M., Bell, A., Craft, A., Crawley, E., David, J., Gardener-Medwin, J., Griffin, J., Hall, A., Hall, M., Herrick, A., Hollingworth, P., Holt, L., Jones, S., ... Venning, H. (2002). Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. Rheumatology, 41(4), 462-465.

@article{c4177b71ed784b7bb7d610d6549c038b,

title = "Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis",

abstract = "Objectives. Juvenile idiopathic arthritis (JIA) is a complex polygenic disorder. The encouraging outcome of anti-tumour necrosis factor (TNF) treatment, as well as serological studies, has implicated TNF and its receptors (TNFRI and TNFRII, or TNFRSF1B) in the pathogenesis of JIA. The purpose of this study was to investigate the exon 6 TNFRII single nucleotide polymorphism (SNP) in a well-defined UK cohort of JIA patients, using case-control association analysis. Methods. A total of 435 patients, spanning seven JIA subgroups, and 261 healthy individuals were screened for the polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results. No significant differences were observed between the SNP allelic or genotypic frequencies of patients and controls, or between JIA subgroups. Conclusions. This TNFRII exon 6 SNP does not seem to be associated with susceptibility to JIA.",

keywords = "Complex genetic disease, Juvenile idiopathic arthritis, Single nucleotide polymorphism, Tumour necrosis factor receptor II",

author = "E. Zeggini and W. Thomson and A. Alansari and W. Ollier and R. Donn and M. Abinun and M. Becker and A. Bell and A. Craft and E. Crawley and J. David and J. Gardener-Medwin and J. Griffin and A. Hall and M. Hall and A. Herrick and P. Hollingworth and L. Holt and S. Jones and G. Pountain and C. Ryder and T. Southwood and I. Stewart and P. Woo and S. Wyatt and H. Venning",

year = "2002",

language = "English",

volume = "41",

pages = "462--465",

journal = "Rheumatology",

issn = "1462-0332",

publisher = "Oxford University Press",

number = "4",

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Zeggini, E, Thomson, W, Alansari, A, Ollier, W , Donn, R, Abinun, M, Becker, M, Bell, A, Craft, A, Crawley, E, David, J, Gardener-Medwin, J, Griffin, J, Hall, A, Hall, M, Herrick, A, Hollingworth, P, Holt, L, Jones, S, Pountain, G, Ryder, C, Southwood, T, Stewart, I, Woo, P, Wyatt, S & Venning, H 2002, 'Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis', Rheumatology, vol. 41, no. 4, pp. 462-465.

TY - JOUR

T1 - Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis

AU - Zeggini, E.

AU - Thomson, W.

AU - Alansari, A.

AU - Ollier, W.

AU - Donn, R.

AU - Abinun, M.

AU - Becker, M.

AU - Bell, A.

AU - Craft, A.

AU - Crawley, E.

AU - David, J.

AU - Gardener-Medwin, J.

AU - Griffin, J.

AU - Hall, A.

AU - Hall, M.

AU - Herrick, A.

AU - Hollingworth, P.

AU - Holt, L.

AU - Jones, S.

AU - Pountain, G.

AU - Ryder, C.

AU - Southwood, T.

AU - Stewart, I.

AU - Woo, P.

AU - Wyatt, S.

AU - Venning, H.

PY - 2002

Y1 - 2002

N2 - Objectives. Juvenile idiopathic arthritis (JIA) is a complex polygenic disorder. The encouraging outcome of anti-tumour necrosis factor (TNF) treatment, as well as serological studies, has implicated TNF and its receptors (TNFRI and TNFRII, or TNFRSF1B) in the pathogenesis of JIA. The purpose of this study was to investigate the exon 6 TNFRII single nucleotide polymorphism (SNP) in a well-defined UK cohort of JIA patients, using case-control association analysis. Methods. A total of 435 patients, spanning seven JIA subgroups, and 261 healthy individuals were screened for the polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results. No significant differences were observed between the SNP allelic or genotypic frequencies of patients and controls, or between JIA subgroups. Conclusions. This TNFRII exon 6 SNP does not seem to be associated with susceptibility to JIA.

AB - Objectives. Juvenile idiopathic arthritis (JIA) is a complex polygenic disorder. The encouraging outcome of anti-tumour necrosis factor (TNF) treatment, as well as serological studies, has implicated TNF and its receptors (TNFRI and TNFRII, or TNFRSF1B) in the pathogenesis of JIA. The purpose of this study was to investigate the exon 6 TNFRII single nucleotide polymorphism (SNP) in a well-defined UK cohort of JIA patients, using case-control association analysis. Methods. A total of 435 patients, spanning seven JIA subgroups, and 261 healthy individuals were screened for the polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results. No significant differences were observed between the SNP allelic or genotypic frequencies of patients and controls, or between JIA subgroups. Conclusions. This TNFRII exon 6 SNP does not seem to be associated with susceptibility to JIA.

KW - Complex genetic disease

KW - Juvenile idiopathic arthritis

KW - Single nucleotide polymorphism

KW - Tumour necrosis factor receptor II

M3 - Article

SN - 1462-0332

VL - 41

SP - 462

EP - 465

JO - Rheumatology

JF - Rheumatology

IS - 4

ER -

Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis

Abstract

Keywords

UN SDGs

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