Tunable silver-functionalized porous frameworks for antibacterial applications

Mark A. Isaacs; Brunella Barbero; Lee J. Durndell; Anthony C. Hilton; Luca Olivi; Christopher M.A. Parlett; Karen Wilson; Adam F. Lee

doi:10.3390/antibiotics7030055

Tunable silver-functionalized porous frameworks for antibacterial applications

Mark A. Isaacs, Brunella Barbero, Lee J. Durndell, Anthony C. Hilton, Luca Olivi, Christopher M.A. Parlett, Karen Wilson^*, Adam F. Lee

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag₂ CO₃ formation and the release of ionic silver in simulated tissue fluid. The Ag₂ CO₃ concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA).

Original language	English
Article number	55
Journal	Antibiotics
Volume	7
Issue number	3
Early online date	3 Jul 2018
DOIs	https://doi.org/10.3390/antibiotics7030055
Publication status	Published - 1 Sept 2018

Keywords

Antibacterial
Macroporous
Mesoporous
Silver
Surface functionalization
Titania

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/antibiotics7030055

UoMaH: The University of Manchester at Harwell
Lawrence, J. (PI), Burnett, T. (PI), Baker, M. (Researcher), Eastwood, D. (Researcher), Hunt, S. (Researcher), Yan, K. (Researcher), Khan, A. (Researcher), Ma, L. (Researcher), Mirihanage, W. (Researcher), Parlett, C. (Researcher), Freitas, D. (Researcher), Reinhard, C. (Support team), Duggins, D. (Technical team), Lewis-Fell, J. (Technical team), Nonni, S. (Technical team), Rollings, B. (Technical team), Sinclair, L. (Technical team) & Batts, S. (Support team)
1/01/18 → …
Project: Other

Cite this

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title = "Tunable silver-functionalized porous frameworks for antibacterial applications",

abstract = "Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag2 CO3 formation and the release of ionic silver in simulated tissue fluid. The Ag2 CO3 concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA).",

keywords = "Antibacterial, Macroporous, Mesoporous, Silver, Surface functionalization, Titania",

author = "Isaacs, {Mark A.} and Brunella Barbero and Durndell, {Lee J.} and Hilton, {Anthony C.} and Luca Olivi and Parlett, {Christopher M.A.} and Karen Wilson and Lee, {Adam F.}",

year = "2018",

month = sep,

day = "1",

doi = "10.3390/antibiotics7030055",

language = "English",

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journal = "Antibiotics",

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TY - JOUR

T1 - Tunable silver-functionalized porous frameworks for antibacterial applications

AU - Isaacs, Mark A.

AU - Barbero, Brunella

AU - Durndell, Lee J.

AU - Hilton, Anthony C.

AU - Olivi, Luca

AU - Parlett, Christopher M.A.

AU - Wilson, Karen

AU - Lee, Adam F.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag2 CO3 formation and the release of ionic silver in simulated tissue fluid. The Ag2 CO3 concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA).

AB - Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag2 CO3 formation and the release of ionic silver in simulated tissue fluid. The Ag2 CO3 concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA).

KW - Antibacterial

KW - Macroporous

KW - Mesoporous

KW - Silver

KW - Surface functionalization

KW - Titania

U2 - 10.3390/antibiotics7030055

DO - 10.3390/antibiotics7030055

M3 - Article

AN - SCOPUS:85050515819

SN - 2079-6382

VL - 7

JO - Antibiotics

JF - Antibiotics

IS - 3

M1 - 55

ER -

Tunable silver-functionalized porous frameworks for antibacterial applications

Abstract

Keywords

UN SDGs

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Projects

UoMaH: The University of Manchester at Harwell

Cite this