Two novel biallelic polymorphisms in the IL-2 gene

S. John; D. Turner; R. Donn; P. Sinnott; J. Worthington; W. E R Ollier; I. V. Hutchinson; A. H. Hajeer

doi:10.1046/j.1365-2370.1998.00139.x

Two novel biallelic polymorphisms in the IL-2 gene

S. John, D. Turner, R. Donn, P. Sinnott, J. Worthington, W. E R Ollier, I. V. Hutchinson, A. H. Hajeer

Research output: Contribution to journal › Article › peer-review

Abstract

We have detected two novel single nucleotide polymorphisms in the IL-2 gene, at positions -330 and +166 relative to the transcription start site. The +166 change occurs within the leader peptide and does not affect amino acid sequence. The -330 polymorphism has two common alleles, making it an ideal marker for genetic association studies.

Original language	English
Pages (from-to)	419-420
Number of pages	1
Journal	European Journal of Immunogenetics
Volume	25
Issue number	6
DOIs	https://doi.org/10.1046/j.1365-2370.1998.00139.x
Publication status	Published - 1998

Keywords

ACADEMIC JOURNAL PAPERS
ORIGINAL ARTICLES

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10.1046/j.1365-2370.1998.00139.x

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title = "Two novel biallelic polymorphisms in the IL-2 gene",

abstract = "We have detected two novel single nucleotide polymorphisms in the IL-2 gene, at positions -330 and +166 relative to the transcription start site. The +166 change occurs within the leader peptide and does not affect amino acid sequence. The -330 polymorphism has two common alleles, making it an ideal marker for genetic association studies.",

keywords = "ACADEMIC JOURNAL PAPERS, ORIGINAL ARTICLES",

author = "S. John and D. Turner and R. Donn and P. Sinnott and J. Worthington and Ollier, {W. E R} and Hutchinson, {I. V.} and Hajeer, {A. H.}",

note = "UI - 99135106 LA - eng RN - 0 (5' Untranslated Regions) RN - 0 (Interleukin-2) PT - Journal Article DA - 19990413 IS - 0960-7420 SB - IM CY - ENGLAND",

year = "1998",

doi = "10.1046/j.1365-2370.1998.00139.x",

language = "English",

volume = "25",

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TY - JOUR

T1 - Two novel biallelic polymorphisms in the IL-2 gene

AU - John, S.

AU - Turner, D.

AU - Donn, R.

AU - Sinnott, P.

AU - Worthington, J.

AU - Ollier, W. E R

AU - Hutchinson, I. V.

AU - Hajeer, A. H.

N1 - UI - 99135106 LA - eng RN - 0 (5' Untranslated Regions) RN - 0 (Interleukin-2) PT - Journal Article DA - 19990413 IS - 0960-7420 SB - IM CY - ENGLAND

PY - 1998

Y1 - 1998

N2 - We have detected two novel single nucleotide polymorphisms in the IL-2 gene, at positions -330 and +166 relative to the transcription start site. The +166 change occurs within the leader peptide and does not affect amino acid sequence. The -330 polymorphism has two common alleles, making it an ideal marker for genetic association studies.

AB - We have detected two novel single nucleotide polymorphisms in the IL-2 gene, at positions -330 and +166 relative to the transcription start site. The +166 change occurs within the leader peptide and does not affect amino acid sequence. The -330 polymorphism has two common alleles, making it an ideal marker for genetic association studies.

KW - ACADEMIC JOURNAL PAPERS

KW - ORIGINAL ARTICLES

U2 - 10.1046/j.1365-2370.1998.00139.x

DO - 10.1046/j.1365-2370.1998.00139.x

M3 - Article

C2 - 9949947

SN - 0960-7420

VL - 25

SP - 419

EP - 420

JO - European Journal of Immunogenetics

JF - European Journal of Immunogenetics

IS - 6

ER -

Two novel biallelic polymorphisms in the IL-2 gene

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