Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium

Jukka T. Salonen; Pekka Uimari; Juha Matti Aalto; Mia Pirskanen; Jari Kaikkonen; Boryana Todorova; Jelena Hyppönen; Veli Pekka Korhonen; Janne Asikainen; Christopher Devine; Tomi Pekka Tuomainen; Jan Luedemann; Matthias Nauck; Wolfgang Kerner; Richard H. Stephens; John P. New; William E. Ollier; J. Martin Gibson; Antony Payton; Michael A. Horan; Neil Pendleton; Walt Mahoney; David Meyre; Jerôme Delplanque; Philippe Froguel; Oren Luzzatto; Benjamin Yakir; Ariel Darvasi

doi:10.1086/520599

Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium

Jukka T. Salonen
, Pekka Uimari
, Juha Matti Aalto
, Mia Pirskanen
, Jari Kaikkonen
, Boryana Todorova
, Jelena Hyppönen
, Veli Pekka Korhonen
, Janne Asikainen
, Christopher Devine
, Tomi Pekka Tuomainen
, Jan Luedemann
, Matthias Nauck
, Wolfgang Kerner
, Richard H. Stephens
, John P. New
, William E. Ollier
, J. Martin Gibson
, Antony Payton
, Michael A. Horan

Neil Pendleton, Walt Mahoney, David Meyre, Jerôme Delplanque, Philippe Froguel, Oren Luzzatto, Benjamin Yakir, Ariel Darvasi

Research output: Contribution to journal › Article › peer-review

Abstract

Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. © 2007 by The American Society of Human Genetics. All rights reserved.

Original language	English
Pages (from-to)	338-345
Number of pages	7
Journal	American Journal of Human Genetics
Volume	81
Issue number	2
DOIs	https://doi.org/10.1086/520599
Publication status	Published - Aug 2007

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10.1086/520599

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Salonen, J. T., Uimari, P., Aalto, J. M., Pirskanen, M., Kaikkonen, J., Todorova, B., Hyppönen, J., Korhonen, V. P., Asikainen, J., Devine, C., Tuomainen, T. P., Luedemann, J., Nauck, M., Kerner, W., Stephens, R. H., New, J. P., Ollier, W. E., Gibson, J. M., Payton, A., ... Darvasi, A. (2007). Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium. American Journal of Human Genetics, 81(2), 338-345. https://doi.org/10.1086/520599

@article{e2b0e060a8544737bac2c784a38c3631,

title = "Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium",

abstract = "Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. {\textcopyright} 2007 by The American Society of Human Genetics. All rights reserved.",

author = "Salonen, \{Jukka T.\} and Pekka Uimari and Aalto, \{Juha Matti\} and Mia Pirskanen and Jari Kaikkonen and Boryana Todorova and Jelena Hypp{\"o}nen and Korhonen, \{Veli Pekka\} and Janne Asikainen and Christopher Devine and Tuomainen, \{Tomi Pekka\} and Jan Luedemann and Matthias Nauck and Wolfgang Kerner and Stephens, \{Richard H.\} and New, \{John P.\} and Ollier, \{William E.\} and Gibson, \{J. Martin\} and Antony Payton and Horan, \{Michael A.\} and Neil Pendleton and Walt Mahoney and David Meyre and Jer{\^o}me Delplanque and Philippe Froguel and Oren Luzzatto and Benjamin Yakir and Ariel Darvasi",

year = "2007",

month = aug,

doi = "10.1086/520599",

language = "English",

volume = "81",

pages = "338--345",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "2",

}

Salonen, JT, Uimari, P, Aalto, JM, Pirskanen, M, Kaikkonen, J, Todorova, B, Hyppönen, J, Korhonen, VP, Asikainen, J, Devine, C, Tuomainen, TP, Luedemann, J, Nauck, M, Kerner, W, Stephens, RH, New, JP , Ollier, WE , Gibson, JM , Payton, A, Horan, MA, Pendleton, N, Mahoney, W, Meyre, D, Delplanque, J, Froguel, P, Luzzatto, O, Yakir, B & Darvasi, A 2007, 'Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium', American Journal of Human Genetics, vol. 81, no. 2, pp. 338-345. https://doi.org/10.1086/520599

TY - JOUR

T1 - Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium

AU - Salonen, Jukka T.

AU - Uimari, Pekka

AU - Aalto, Juha Matti

AU - Pirskanen, Mia

AU - Kaikkonen, Jari

AU - Todorova, Boryana

AU - Hyppönen, Jelena

AU - Korhonen, Veli Pekka

AU - Asikainen, Janne

AU - Devine, Christopher

AU - Tuomainen, Tomi Pekka

AU - Luedemann, Jan

AU - Nauck, Matthias

AU - Kerner, Wolfgang

AU - Stephens, Richard H.

AU - New, John P.

AU - Ollier, William E.

AU - Gibson, J. Martin

AU - Payton, Antony

AU - Horan, Michael A.

AU - Pendleton, Neil

AU - Mahoney, Walt

AU - Meyre, David

AU - Delplanque, Jerôme

AU - Froguel, Philippe

AU - Luzzatto, Oren

AU - Yakir, Benjamin

AU - Darvasi, Ariel

PY - 2007/8

Y1 - 2007/8

N2 - Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. © 2007 by The American Society of Human Genetics. All rights reserved.

AB - Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. © 2007 by The American Society of Human Genetics. All rights reserved.

U2 - 10.1086/520599

DO - 10.1086/520599

M3 - Article

C2 - 17668382

SN - 0002-9297

VL - 81

SP - 338

EP - 345

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 2

ER -

Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium

Abstract

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