Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium

Jukka T. Salonen; Pekka Uimari; Juha Matti Aalto; Mia Pirskanen; Jari Kaikkonen; Boryana Todorova; Jelena Hyppönen; Veli Pekka Korhonen; Janne Asikainen; Christopher Devine; Tomi Pekka Tuomainen; Jan Luedemann; Matthias Nauck; Wolfgang Kerner; Richard H. Stephens; John P. New; William E. Ollier; J. Martin Gibson; Antony Payton; Michael A. Horan; Neil Pendleton; Walt Mahoney; David Meyre; Jerôme Delplanque; Philippe Froguel; Oren Luzzatto; Benjamin Yakir; Ariel Darvasi

doi:10.1086/520599

Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium

Jukka T. Salonen, Pekka Uimari, Juha Matti Aalto, Mia Pirskanen, Jari Kaikkonen, Boryana Todorova, Jelena Hyppönen, Veli Pekka Korhonen, Janne Asikainen, Christopher Devine, Tomi Pekka Tuomainen, Jan Luedemann, Matthias Nauck, Wolfgang Kerner, Richard H. Stephens, John P. New, William E. Ollier, J. Martin Gibson, Antony Payton, Michael A. HoranNeil Pendleton, Walt Mahoney, David Meyre, Jerôme Delplanque, Philippe Froguel, Oren Luzzatto, Benjamin Yakir, Ariel Darvasi

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Abstract

Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. © 2007 by The American Society of Human Genetics. All rights reserved.

Original language	English
Pages (from-to)	338-345
Number of pages	7
Journal	American Journal of Human Genetics
Volume	81
Issue number	2
DOIs	https://doi.org/10.1086/520599
Publication status	Published - Aug 2007

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Salonen, J. T., Uimari, P., Aalto, J. M., Pirskanen, M., Kaikkonen, J., Todorova, B., Hyppönen, J., Korhonen, V. P., Asikainen, J., Devine, C., Tuomainen, T. P., Luedemann, J., Nauck, M., Kerner, W., Stephens, R. H., New, J. P., Ollier, W. E., Gibson, J. M., Payton, A., ... Darvasi, A. (2007). Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium. American Journal of Human Genetics, 81(2), 338-345. https://doi.org/10.1086/520599

@article{e2b0e060a8544737bac2c784a38c3631,

title = "Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium",

abstract = "Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. {\textcopyright} 2007 by The American Society of Human Genetics. All rights reserved.",

author = "Salonen, \{Jukka T.\} and Pekka Uimari and Aalto, \{Juha Matti\} and Mia Pirskanen and Jari Kaikkonen and Boryana Todorova and Jelena Hypp{\"o}nen and Korhonen, \{Veli Pekka\} and Janne Asikainen and Christopher Devine and Tuomainen, \{Tomi Pekka\} and Jan Luedemann and Matthias Nauck and Wolfgang Kerner and Stephens, \{Richard H.\} and New, \{John P.\} and Ollier, \{William E.\} and Gibson, \{J. Martin\} and Antony Payton and Horan, \{Michael A.\} and Neil Pendleton and Walt Mahoney and David Meyre and Jer{\^o}me Delplanque and Philippe Froguel and Oren Luzzatto and Benjamin Yakir and Ariel Darvasi",

year = "2007",

month = aug,

doi = "10.1086/520599",

language = "English",

volume = "81",

pages = "338--345",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "2",

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Salonen, JT, Uimari, P, Aalto, JM, Pirskanen, M, Kaikkonen, J, Todorova, B, Hyppönen, J, Korhonen, VP, Asikainen, J, Devine, C, Tuomainen, TP, Luedemann, J, Nauck, M, Kerner, W, Stephens, RH, New, JP , Ollier, WE , Gibson, JM , Payton, A, Horan, MA, Pendleton, N, Mahoney, W, Meyre, D, Delplanque, J, Froguel, P, Luzzatto, O, Yakir, B & Darvasi, A 2007, 'Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium', American Journal of Human Genetics, vol. 81, no. 2, pp. 338-345. https://doi.org/10.1086/520599

TY - JOUR

T1 - Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium

AU - Salonen, Jukka T.

AU - Uimari, Pekka

AU - Aalto, Juha Matti

AU - Pirskanen, Mia

AU - Kaikkonen, Jari

AU - Todorova, Boryana

AU - Hyppönen, Jelena

AU - Korhonen, Veli Pekka

AU - Asikainen, Janne

AU - Devine, Christopher

AU - Tuomainen, Tomi Pekka

AU - Luedemann, Jan

AU - Nauck, Matthias

AU - Kerner, Wolfgang

AU - Stephens, Richard H.

AU - New, John P.

AU - Ollier, William E.

AU - Gibson, J. Martin

AU - Payton, Antony

AU - Horan, Michael A.

AU - Pendleton, Neil

AU - Mahoney, Walt

AU - Meyre, David

AU - Delplanque, Jerôme

AU - Froguel, Philippe

AU - Luzzatto, Oren

AU - Yakir, Benjamin

AU - Darvasi, Ariel

PY - 2007/8

Y1 - 2007/8

N2 - Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. © 2007 by The American Society of Human Genetics. All rights reserved.

AB - Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. © 2007 by The American Society of Human Genetics. All rights reserved.

UR - https://www.scopus.com/pages/publications/34547755055

U2 - 10.1086/520599

DO - 10.1086/520599

M3 - Article

C2 - 17668382

SN - 0002-9297

VL - 81

SP - 338

EP - 345

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 2

ER -

Type 2 diabetes whole-genome association study in four populations: The DiaGen consortium

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