Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.

William C Gause; Thomas A Wynn; Judith E Allen

doi:10.1038/nri3476

Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.

William C Gause, Thomas A Wynn, Judith E Allen

The University of Manchester

Research output: Contribution to journal › Article › peer-review

Abstract

Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.

Original language	English
Journal	Nature reviews. Immunology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1038/nri3476
Publication status	Published - Aug 2013

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abstract = "Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.",

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Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.

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