Ultra fast bone-like apatite formation on highly porous poly(l-lactic acid)-hydroxyapatite fibres

Jing Zhu, Dexin Tang, Zihan Lu, Zhiying Xin, Jun Song, Jinmin Meng, Jian Ren Lu, Zhi Li, Jiashen Li (Corresponding)

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Abstract

In order to provide a favourable environment for living bone formation, it is an essential condition to grow bone-like apatite layer at the interface between the tissue-implant and its surrounding tissues. Inspired by the chemical composition and the nano porous structure of natural bones, we developed an ultrafast and accessible route to accelerate effectively the formation of bone-like apatite on the surface of porous poly(L-lactic acid)-hydroxyapatite (PLLA-HA) composite fibres in 5 times simulated body fluid (5SBF). The key of the method lies in successful exposure of HA nanoparticles on the surface of PLLA fibres by acetone treatment of electrospun PLLA-HA nano/micro fibres. The recrystallization of PLLA chains uncovers more HA nanoparticles on the surface of every fibre which provide nucleation sites for calcium and phosphate ions. After only 2 hours of immersing in 5SBF, a full layer of apatite completely covered on the surface of porous PLLA-HA fibres. The results indicate that HA nanoparticles on porous fibre surface can accelerate the kinetic deposition of apatite on fibre surface. Biological in vitro cell culture with human osteoblast-like cell for up to 7 days demonstrates that the incorporation of HA nanoparticles on the surface of porous PLLA fibrous membranes leads to significant enhance osteoblast adhesion and proliferation. The route can open avenues for development of fibrous PLLA biomaterials for hard tissue repair and substitution.
Original languageEnglish
Article number111168
Number of pages13
JournalMaterials Science and Engineering C: Materials for Biological Applications
DOIs
Publication statusPublished - 6 Jun 2020

Keywords

  • hydroxyapatite
  • mineralization
  • poly(L lactic acid)
  • electrospinning
  • porous fibre

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