Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma

Lucas D Trucco; Piyushkumar A Mundra; Kate Hogan; Pablo Garcia-Martinez; Amaya Viros; Amit K Mandal; Nicolas Macagno; Caroline Gaudy-Marqueste; Donald Allan; Franziska Baenke; Martin Cook; Clare McManus; Berta Sanchez-Laorden; Nathalie Dhomen; Richard Marais

doi:10.1038/s41591-018-0265-6

Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma

Lucas D Trucco, Piyushkumar A Mundra, Kate Hogan, Pablo Garcia-Martinez, Amaya Viros, Amit K Mandal, Nicolas Macagno, Caroline Gaudy-Marqueste, Donald Allan, Franziska Baenke, Martin Cook, Clare McManus, Berta Sanchez-Laorden, Nathalie Dhomen, Richard Marais

Aix-Marseille University

Research output: Contribution to journal › Article › peer-review

Abstract

The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

Original language	English
Pages (from-to)	221-224
Number of pages	4
Journal	Nature Medicine
Volume	25
Issue number	2
DOIs	https://doi.org/10.1038/s41591-018-0265-6
Publication status	Published - 3 Dec 2018

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Manchester Cancer Research Centre

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10.1038/s41591-018-0265-6

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Trucco, L. D., Mundra, P. A., Hogan, K., Garcia-Martinez, P., Viros, A., Mandal, A. K., Macagno, N., Gaudy-Marqueste, C., Allan, D., Baenke, F., Cook, M., McManus, C., Sanchez-Laorden, B., Dhomen, N., & Marais, R. (2018). Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. Nature Medicine, 25(2), 221-224. https://doi.org/10.1038/s41591-018-0265-6

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title = "Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma",

abstract = "The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.",

author = "Trucco, \{Lucas D\} and Mundra, \{Piyushkumar A\} and Kate Hogan and Pablo Garcia-Martinez and Amaya Viros and Mandal, \{Amit K\} and Nicolas Macagno and Caroline Gaudy-Marqueste and Donald Allan and Franziska Baenke and Martin Cook and Clare McManus and Berta Sanchez-Laorden and Nathalie Dhomen and Richard Marais",

note = "Funding Information: This work was supported by CRUK-MI (A27412 and A22902) and the European Research Council (ERC Advanced Grant agreement No. 671262) to R.M. C.G-M. was supported by the French Society of Dermatology, UNICANCER and CEDEF. We acknowledge the contribution of the CRUK-MI core facilities and the contribution of the melanoma specimen donors. Publisher Copyright: {\textcopyright} 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

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doi = "10.1038/s41591-018-0265-6",

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T1 - Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma

AU - Trucco, Lucas D

AU - Mundra, Piyushkumar A

AU - Hogan, Kate

AU - Garcia-Martinez, Pablo

AU - Viros, Amaya

AU - Mandal, Amit K

AU - Macagno, Nicolas

AU - Gaudy-Marqueste, Caroline

AU - Allan, Donald

AU - Baenke, Franziska

AU - Cook, Martin

AU - McManus, Clare

AU - Sanchez-Laorden, Berta

AU - Dhomen, Nathalie

AU - Marais, Richard

N1 - Funding Information: This work was supported by CRUK-MI (A27412 and A22902) and the European Research Council (ERC Advanced Grant agreement No. 671262) to R.M. C.G-M. was supported by the French Society of Dermatology, UNICANCER and CEDEF. We acknowledge the contribution of the CRUK-MI core facilities and the contribution of the melanoma specimen donors. Publisher Copyright: © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2018/12/3

Y1 - 2018/12/3

N2 - The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

AB - The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

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DO - 10.1038/s41591-018-0265-6

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EP - 224

JO - Nature Medicine

JF - Nature Medicine

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ER -

Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma

Abstract

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