Understanding the role of SOX9 in acquired diseases: lessons from development

Research output: Contribution to journalArticlepeer-review


The transcription factor SOX9 is crucial for multiple aspects of development. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder concordant with the expression profile of SOX9 during embryogenesis. The mechanistic understanding of development has revealed roles for SOX9 in regulating cartilage extracellular matrix (ECM) production and cell proliferation, among others. More recently, it transpires that SOX9 becomes expressed and induces destructive ECM components in organ fibrosis and related disorders. Although commonly absent from the parent cell type, SOX9 is expressed in a wide range of cancers, where it regulates cell proliferation. These data have potential diagnostic, prognostic and therapeutic relevance, suggesting that disease mechanisms might result from re-expressing this developmental transcription factor in ectopic locations.

Original languageEnglish
Pages (from-to)166-174
Number of pages9
JournalTrends in molecular medicine
Issue number3
Publication statusPublished - Mar 2011


  • Animals
  • Disease
  • Gene Expression Regulation, Developmental
  • Humans
  • SOX9 Transcription Factor
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review


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