Unequal sister chromatid exchange in the rDNA array of Saccharomyces cerevisiae

M. Motovali-Bashi; Z. Hojati; R. M. Walmsley

doi:10.1016/j.mrgentox.2004.08.004

Unequal sister chromatid exchange in the rDNA array of Saccharomyces cerevisiae

M. Motovali-Bashi, Z. Hojati, R. M. Walmsley

Research output: Contribution to journal › Article › peer-review

Abstract

In the yeast Saccharomyces cerevisiae the nucleolar organiser region (NOR) is located on chromosome XII. It contains 100-200 copies of rDNA - a minimum of 20 rDNA genes in tandem - and is termed the RDN locus. Yeast cells may exist in either haploid or diploid form. There are two forms of life cycle: haploid and diploid cells double by mitosis, and diploid cells are reduced to the haploid state by meiosis. Diploid cells have two homologous chromosomes for each of the 16 chromosomes. They are usually of the same size. However, in this study it is shown that homologous chromosomes XII can become different in size due to unequal sister chromatid exchange during mitosis in 'old' cells. © 2004 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	129-137
Number of pages	8
Journal	Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume	564
Issue number	2
DOIs	https://doi.org/10.1016/j.mrgentox.2004.08.004
Publication status	Published - 12 Dec 2004

Keywords

Chromosome XII
Double strand break (DSB)
Homologous chromosome
RDN locus
rDNA genes
Saccharomyces cerevisiae
Unequal sister chromatid exchange

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10.1016/j.mrgentox.2004.08.004

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title = "Unequal sister chromatid exchange in the rDNA array of Saccharomyces cerevisiae",

abstract = "In the yeast Saccharomyces cerevisiae the nucleolar organiser region (NOR) is located on chromosome XII. It contains 100-200 copies of rDNA - a minimum of 20 rDNA genes in tandem - and is termed the RDN locus. Yeast cells may exist in either haploid or diploid form. There are two forms of life cycle: haploid and diploid cells double by mitosis, and diploid cells are reduced to the haploid state by meiosis. Diploid cells have two homologous chromosomes for each of the 16 chromosomes. They are usually of the same size. However, in this study it is shown that homologous chromosomes XII can become different in size due to unequal sister chromatid exchange during mitosis in 'old' cells. {\textcopyright} 2004 Elsevier B.V. All rights reserved.",

keywords = "Chromosome XII, Double strand break (DSB), Homologous chromosome, RDN locus, rDNA genes, Saccharomyces cerevisiae, Unequal sister chromatid exchange",

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TY - JOUR

T1 - Unequal sister chromatid exchange in the rDNA array of Saccharomyces cerevisiae

AU - Motovali-Bashi, M.

AU - Hojati, Z.

AU - Walmsley, R. M.

PY - 2004/12/12

Y1 - 2004/12/12

N2 - In the yeast Saccharomyces cerevisiae the nucleolar organiser region (NOR) is located on chromosome XII. It contains 100-200 copies of rDNA - a minimum of 20 rDNA genes in tandem - and is termed the RDN locus. Yeast cells may exist in either haploid or diploid form. There are two forms of life cycle: haploid and diploid cells double by mitosis, and diploid cells are reduced to the haploid state by meiosis. Diploid cells have two homologous chromosomes for each of the 16 chromosomes. They are usually of the same size. However, in this study it is shown that homologous chromosomes XII can become different in size due to unequal sister chromatid exchange during mitosis in 'old' cells. © 2004 Elsevier B.V. All rights reserved.

AB - In the yeast Saccharomyces cerevisiae the nucleolar organiser region (NOR) is located on chromosome XII. It contains 100-200 copies of rDNA - a minimum of 20 rDNA genes in tandem - and is termed the RDN locus. Yeast cells may exist in either haploid or diploid form. There are two forms of life cycle: haploid and diploid cells double by mitosis, and diploid cells are reduced to the haploid state by meiosis. Diploid cells have two homologous chromosomes for each of the 16 chromosomes. They are usually of the same size. However, in this study it is shown that homologous chromosomes XII can become different in size due to unequal sister chromatid exchange during mitosis in 'old' cells. © 2004 Elsevier B.V. All rights reserved.

KW - Chromosome XII

KW - Double strand break (DSB)

KW - Homologous chromosome

KW - RDN locus

KW - rDNA genes

KW - Saccharomyces cerevisiae

KW - Unequal sister chromatid exchange

U2 - 10.1016/j.mrgentox.2004.08.004

DO - 10.1016/j.mrgentox.2004.08.004

M3 - Article

SN - 1383-5718

VL - 564

SP - 129

EP - 137

JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis

JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis

IS - 2

ER -

Unequal sister chromatid exchange in the rDNA array of Saccharomyces cerevisiae

Abstract

Keywords

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