Unintended positive and negative effects of drugs on lipoproteins.

Tarza J Siahmansur; Jonathan D Schofield; Shazli Azmi; Yifen Liu; Paul N Durrington; Handrean Soran

doi:10.1097/MOL.0000000000000198

Unintended positive and negative effects of drugs on lipoproteins.

Tarza J Siahmansur, Jonathan D Schofield, Shazli Azmi, Yifen Liu, Paul N Durrington, Handrean Soran

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE OF REVIEW: Dyslipidaemia is an important cardiovascular disease risk factor. Many drugs affect lipid profile and lipoprotein metabolism. We reviewed unintended effects of nonlipid modifying, commonly used medications on lipid profile and lipoprotein metabolism. RECENT FINDING: Several detrimental effects of many drug classes such as diuretics, antidepressant, anticonvulsant and antiretroviral drugs have been reported, whereas other drug classes such as antiobesity, alpha 1-blockers, oestrogens and thyroid replacement therapy were associated with positive effects. SUMMARY: Dyslipidaemia is a common side-effect of many medications. This should be taken into consideration, especially in patients at high risk of cardiovascular disease. Other drugs demonstrated positive effects on circulating lipids and lipoproteins. The impact of these unintended effects on atherosclerotic disease risk and progression is unclear.

Original language	English
Journal	Current opinion in lipidology
DOIs	https://doi.org/10.1097/MOL.0000000000000198
Publication status	Published - 22 Jun 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/MOL.0000000000000198

Cite this

@article{4da80d2e3ee64510af24838a2b5d6f93,

title = "Unintended positive and negative effects of drugs on lipoproteins.",

abstract = "PURPOSE OF REVIEW: Dyslipidaemia is an important cardiovascular disease risk factor. Many drugs affect lipid profile and lipoprotein metabolism. We reviewed unintended effects of nonlipid modifying, commonly used medications on lipid profile and lipoprotein metabolism. RECENT FINDING: Several detrimental effects of many drug classes such as diuretics, antidepressant, anticonvulsant and antiretroviral drugs have been reported, whereas other drug classes such as antiobesity, alpha 1-blockers, oestrogens and thyroid replacement therapy were associated with positive effects. SUMMARY: Dyslipidaemia is a common side-effect of many medications. This should be taken into consideration, especially in patients at high risk of cardiovascular disease. Other drugs demonstrated positive effects on circulating lipids and lipoproteins. The impact of these unintended effects on atherosclerotic disease risk and progression is unclear.",

author = "Siahmansur, {Tarza J} and Schofield, {Jonathan D} and Shazli Azmi and Yifen Liu and Durrington, {Paul N} and Handrean Soran",

year = "2015",

month = jun,

day = "22",

doi = "10.1097/MOL.0000000000000198",

language = "English",

journal = "Current opinion in lipidology",

issn = "1473-6535",

publisher = "Lippincott Williams & Wilkins",

}

TY - JOUR

T1 - Unintended positive and negative effects of drugs on lipoproteins.

AU - Siahmansur, Tarza J

AU - Schofield, Jonathan D

AU - Azmi, Shazli

AU - Liu, Yifen

AU - Durrington, Paul N

AU - Soran, Handrean

PY - 2015/6/22

Y1 - 2015/6/22

N2 - PURPOSE OF REVIEW: Dyslipidaemia is an important cardiovascular disease risk factor. Many drugs affect lipid profile and lipoprotein metabolism. We reviewed unintended effects of nonlipid modifying, commonly used medications on lipid profile and lipoprotein metabolism. RECENT FINDING: Several detrimental effects of many drug classes such as diuretics, antidepressant, anticonvulsant and antiretroviral drugs have been reported, whereas other drug classes such as antiobesity, alpha 1-blockers, oestrogens and thyroid replacement therapy were associated with positive effects. SUMMARY: Dyslipidaemia is a common side-effect of many medications. This should be taken into consideration, especially in patients at high risk of cardiovascular disease. Other drugs demonstrated positive effects on circulating lipids and lipoproteins. The impact of these unintended effects on atherosclerotic disease risk and progression is unclear.

AB - PURPOSE OF REVIEW: Dyslipidaemia is an important cardiovascular disease risk factor. Many drugs affect lipid profile and lipoprotein metabolism. We reviewed unintended effects of nonlipid modifying, commonly used medications on lipid profile and lipoprotein metabolism. RECENT FINDING: Several detrimental effects of many drug classes such as diuretics, antidepressant, anticonvulsant and antiretroviral drugs have been reported, whereas other drug classes such as antiobesity, alpha 1-blockers, oestrogens and thyroid replacement therapy were associated with positive effects. SUMMARY: Dyslipidaemia is a common side-effect of many medications. This should be taken into consideration, especially in patients at high risk of cardiovascular disease. Other drugs demonstrated positive effects on circulating lipids and lipoproteins. The impact of these unintended effects on atherosclerotic disease risk and progression is unclear.

U2 - 10.1097/MOL.0000000000000198

DO - 10.1097/MOL.0000000000000198

M3 - Article

C2 - 26103613

SN - 1473-6535

JO - Current opinion in lipidology

JF - Current opinion in lipidology

ER -

Unintended positive and negative effects of drugs on lipoproteins.

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this