Unique binding site for bis-benzimidazoles on transfer RNA

S. E Sadat Ebrahimi; Amanda N. Wilton; Kenneth T. Douglas

Unique binding site for bis-benzimidazoles on transfer RNA

S. E Sadat Ebrahimi, Amanda N. Wilton, Kenneth T. Douglas

Research output: Contribution to journal › Article › peer-review

Abstract

Ligands based on bis-benzimidazole structures related to Hoechst 33258 bind to transfer RNA with 1:1 stoichiometry and dissociation constants in the micromolar range, their interaction appearing significantly different in nature from that with duplex DNA, based on the ribonucleic acid-induced quenching of their fluorescence.

Original language	English
Pages (from-to)	385-386
Number of pages	1
Journal	Chemical Communications
Issue number	4
Publication status	Published - 1997

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@article{936e9a1a138742a9808528524614abf5,

title = "Unique binding site for bis-benzimidazoles on transfer RNA",

abstract = "Ligands based on bis-benzimidazole structures related to Hoechst 33258 bind to transfer RNA with 1:1 stoichiometry and dissociation constants in the micromolar range, their interaction appearing significantly different in nature from that with duplex DNA, based on the ribonucleic acid-induced quenching of their fluorescence.",

author = "Ebrahimi, {S. E Sadat} and Wilton, {Amanda N.} and Douglas, {Kenneth T.}",

year = "1997",

language = "English",

pages = "385--386",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "4",

}

TY - JOUR

T1 - Unique binding site for bis-benzimidazoles on transfer RNA

AU - Ebrahimi, S. E Sadat

AU - Wilton, Amanda N.

AU - Douglas, Kenneth T.

PY - 1997

Y1 - 1997

N2 - Ligands based on bis-benzimidazole structures related to Hoechst 33258 bind to transfer RNA with 1:1 stoichiometry and dissociation constants in the micromolar range, their interaction appearing significantly different in nature from that with duplex DNA, based on the ribonucleic acid-induced quenching of their fluorescence.

AB - Ligands based on bis-benzimidazole structures related to Hoechst 33258 bind to transfer RNA with 1:1 stoichiometry and dissociation constants in the micromolar range, their interaction appearing significantly different in nature from that with duplex DNA, based on the ribonucleic acid-induced quenching of their fluorescence.

M3 - Article

SN - 1359-7345

SP - 385

EP - 386

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

Unique binding site for bis-benzimidazoles on transfer RNA

Abstract

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