Unique TCR β-subunit variable gene haplotypes in Africans

Ian J. Donaldson; Jahan Shefta; Cathy A. Lawson; James R. Bushnell; Ann W. Morgan; John D. Isaacs; Danielle Carpenter; Marie Anne Shaw; Ingegerd Rooth; Rupert J. Quinnell; Alimuddin M. Zumla; William E. Ollier; Chifumbe Z. Chintu; Gabriel P. Muyinda; Adrian V. Hill; Arthur W. Boylston

doi:10.1007/s00251-001-0406-8

Unique TCR β-subunit variable gene haplotypes in Africans

Ian J. Donaldson, Jahan Shefta, Cathy A. Lawson, James R. Bushnell, Ann W. Morgan, John D. Isaacs, Danielle Carpenter, Marie Anne Shaw, Ingegerd Rooth, Rupert J. Quinnell, Alimuddin M. Zumla, William E. Ollier, Chifumbe Z. Chintu, Gabriel P. Muyinda, Adrian V. Hill, Arthur W. Boylston

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated polymorphisms of genes in two regions of the T-cell antigen receptor beta-subunit (TCRB) locus, including BV9S2P, and BV6S7 in a 5' linkage group, and BV8S3, BV24S1, BV25S1, BV18S1, BV2S1, BV15S1 and BV3S1 in a 3' linkage group. These loci have been genotyped in individuals from five regions in Africa, including The Gambia, Nigeria, Cameroon, Tanzania, and Zambia, and in individuals from northern Britain, northern India, and Papua New Guinea (PNG). In the 3' linkage group, 11 unique haplotypes were identified in the combined African populations; two equally frequent haplotypes represent the majority of African chromosomes. One haplotype was found in all four regions studied. This is the most frequent haplotype in the northern British, northern Indian and PNG populations. Although present, it is infrequent in the African populations. A North-South gradient in the frequency of a common African haplotype was observed. The distribution did not represent that of a known disease. Evidence suggests that malaria is not responsible for selection of these haplotypes. Overall, this study highlights large differences in the genetic constitution of the TCRB locus between Africans and other populations

Original language	English
Pages (from-to)	884-893
Number of pages	9
Journal	Immunogenetics
Volume	53
Issue number	10-11
DOIs	https://doi.org/10.1007/s00251-001-0406-8
Publication status	Published - 2002

Keywords

Africa
Caucasoid Race
Complementarity Determining Regions
Disease
Gene Frequency
Genes,T-Cell Receptor beta
genetics
Geography
Great Britain
Haplotypes
Human
immunology
India
Negroid Race
Phenotype
Polymerase Chain Reaction
Polymorphism,Restriction Fragment Length
Protein Subunits
Receptors,Antigen,T-Cell,alpha-beta
Support,Non-U.S.Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00251-001-0406-8

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Donaldson, I. J., Shefta, J., Lawson, C. A., Bushnell, J. R., Morgan, A. W., Isaacs, J. D., Carpenter, D., Shaw, M. A., Rooth, I., Quinnell, R. J., Zumla, A. M., Ollier, W. E., Chintu, C. Z., Muyinda, G. P., Hill, A. V., & Boylston, A. W. (2002). Unique TCR β-subunit variable gene haplotypes in Africans. Immunogenetics, 53(10-11), 884-893. https://doi.org/10.1007/s00251-001-0406-8

@article{d8428775e5bc4d9a8dc60f165727c7ba,

title = "Unique TCR β-subunit variable gene haplotypes in Africans",

abstract = "This study investigated polymorphisms of genes in two regions of the T-cell antigen receptor beta-subunit (TCRB) locus, including BV9S2P, and BV6S7 in a 5' linkage group, and BV8S3, BV24S1, BV25S1, BV18S1, BV2S1, BV15S1 and BV3S1 in a 3' linkage group. These loci have been genotyped in individuals from five regions in Africa, including The Gambia, Nigeria, Cameroon, Tanzania, and Zambia, and in individuals from northern Britain, northern India, and Papua New Guinea (PNG). In the 3' linkage group, 11 unique haplotypes were identified in the combined African populations; two equally frequent haplotypes represent the majority of African chromosomes. One haplotype was found in all four regions studied. This is the most frequent haplotype in the northern British, northern Indian and PNG populations. Although present, it is infrequent in the African populations. A North-South gradient in the frequency of a common African haplotype was observed. The distribution did not represent that of a known disease. Evidence suggests that malaria is not responsible for selection of these haplotypes. Overall, this study highlights large differences in the genetic constitution of the TCRB locus between Africans and other populations",

keywords = "Africa, Caucasoid Race, Complementarity Determining Regions, Disease, Gene Frequency, Genes,T-Cell Receptor beta, genetics, Geography, Great Britain, Haplotypes, Human, immunology, India, Negroid Race, Phenotype, Polymerase Chain Reaction, Polymorphism,Restriction Fragment Length, Protein Subunits, Receptors,Antigen,T-Cell,alpha-beta, Support,Non-U.S.Gov't",

author = "Donaldson, {Ian J.} and Jahan Shefta and Lawson, {Cathy A.} and Bushnell, {James R.} and Morgan, {Ann W.} and Isaacs, {John D.} and Danielle Carpenter and Shaw, {Marie Anne} and Ingegerd Rooth and Quinnell, {Rupert J.} and Zumla, {Alimuddin M.} and Ollier, {William E.} and Chintu, {Chifumbe Z.} and Muyinda, {Gabriel P.} and Hill, {Adrian V.} and Boylston, {Arthur W.}",

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year = "2002",

doi = "10.1007/s00251-001-0406-8",

language = "English",

volume = "53",

pages = "884--893",

journal = "Immunogenetics",

issn = "1432-1211",

publisher = "Springer Nature",

number = "10-11",

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TY - JOUR

T1 - Unique TCR β-subunit variable gene haplotypes in Africans

AU - Donaldson, Ian J.

AU - Shefta, Jahan

AU - Lawson, Cathy A.

AU - Bushnell, James R.

AU - Morgan, Ann W.

AU - Isaacs, John D.

AU - Carpenter, Danielle

AU - Shaw, Marie Anne

AU - Rooth, Ingegerd

AU - Quinnell, Rupert J.

AU - Zumla, Alimuddin M.

AU - Ollier, William E.

AU - Chintu, Chifumbe Z.

AU - Muyinda, Gabriel P.

AU - Hill, Adrian V.

AU - Boylston, Arthur W.

N1 - UI - 21850504DA - 20020306IS - 0093-7711LA - engPT - Journal ArticleRN - 0 (Complementarity Determining Regions)RN - 0 (Protein Subunits)RN - 0 (Receptors, Antigen, T-Cell, alpha-beta)SB - IM

PY - 2002

Y1 - 2002

N2 - This study investigated polymorphisms of genes in two regions of the T-cell antigen receptor beta-subunit (TCRB) locus, including BV9S2P, and BV6S7 in a 5' linkage group, and BV8S3, BV24S1, BV25S1, BV18S1, BV2S1, BV15S1 and BV3S1 in a 3' linkage group. These loci have been genotyped in individuals from five regions in Africa, including The Gambia, Nigeria, Cameroon, Tanzania, and Zambia, and in individuals from northern Britain, northern India, and Papua New Guinea (PNG). In the 3' linkage group, 11 unique haplotypes were identified in the combined African populations; two equally frequent haplotypes represent the majority of African chromosomes. One haplotype was found in all four regions studied. This is the most frequent haplotype in the northern British, northern Indian and PNG populations. Although present, it is infrequent in the African populations. A North-South gradient in the frequency of a common African haplotype was observed. The distribution did not represent that of a known disease. Evidence suggests that malaria is not responsible for selection of these haplotypes. Overall, this study highlights large differences in the genetic constitution of the TCRB locus between Africans and other populations

AB - This study investigated polymorphisms of genes in two regions of the T-cell antigen receptor beta-subunit (TCRB) locus, including BV9S2P, and BV6S7 in a 5' linkage group, and BV8S3, BV24S1, BV25S1, BV18S1, BV2S1, BV15S1 and BV3S1 in a 3' linkage group. These loci have been genotyped in individuals from five regions in Africa, including The Gambia, Nigeria, Cameroon, Tanzania, and Zambia, and in individuals from northern Britain, northern India, and Papua New Guinea (PNG). In the 3' linkage group, 11 unique haplotypes were identified in the combined African populations; two equally frequent haplotypes represent the majority of African chromosomes. One haplotype was found in all four regions studied. This is the most frequent haplotype in the northern British, northern Indian and PNG populations. Although present, it is infrequent in the African populations. A North-South gradient in the frequency of a common African haplotype was observed. The distribution did not represent that of a known disease. Evidence suggests that malaria is not responsible for selection of these haplotypes. Overall, this study highlights large differences in the genetic constitution of the TCRB locus between Africans and other populations

KW - Africa

KW - Caucasoid Race

KW - Complementarity Determining Regions

KW - Disease

KW - Gene Frequency

KW - Genes,T-Cell Receptor beta

KW - genetics

KW - Geography

KW - Great Britain

KW - Haplotypes

KW - Human

KW - immunology

KW - India

KW - Negroid Race

KW - Phenotype

KW - Polymerase Chain Reaction

KW - Polymorphism,Restriction Fragment Length

KW - Protein Subunits

KW - Receptors,Antigen,T-Cell,alpha-beta

KW - Support,Non-U.S.Gov't

U2 - 10.1007/s00251-001-0406-8

DO - 10.1007/s00251-001-0406-8

M3 - Article

C2 - 11862388

SN - 1432-1211

VL - 53

SP - 884

EP - 893

JO - Immunogenetics

JF - Immunogenetics

IS - 10-11

ER -

Unique TCR β-subunit variable gene haplotypes in Africans

Abstract

Keywords

UN SDGs

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