Projects per year
Microstructural equivalence (Q3) for dry powder inhalers (DPIs) is complex because it involves both pre- and post-aerosolization powders and can be influenced by the DPI device and the patient’s aerosolization efficiency. In this paper, we show how advanced 3D X-ray microscopy (XRM, also known as X-ray computed tomography) techniques can provide unique microstructural insights into pre-aerosolized inhalation powders. Nano-scale XRM is used to detect differences within individual lactose particles and agglomerates, including voids and intra-agglomerate size distributions. Micro-scale XRM is used to visualize and quantify lactose fines (<12 m) within a powder bed. XRM is also used to discriminate between excipient and terbutaline sulphate particles in an inhalation blend. These advanced XRM techniques could provide valuable microstructural information to help address Q3 equivalence during bioequivalence determination in inhalation drug products.
|Title of host publication||Respiratory Drug Delivery 2020|
|Publication status||Published - 26 Apr 2020|
|Event||Respiratory Drug Delivery 2020 Digital - |
Duration: 26 Apr 2020 → 30 Jun 2020
|Conference||Respiratory Drug Delivery 2020 Digital|
|Abbreviated title||Digital RDD2020|
|Period||26/04/20 → 30/06/20|
FingerprintDive into the research topics of 'Unlocking the Microstructure of Inhalation Blends using X-ray Microscopy'. Together they form a unique fingerprint.
- 2 Finished
INFORM 2020 - Molecules to Manufacture: Processing and Formulation Engineering of Inhalable Nanoaggregates and Microparticles
1/10/16 → 31/01/21
Structural Evolution across multiple time and length scales
Withers, P., Cartmell, S., Cernik, R., Derby, B., Eichhorn, S., Freemont, A., Hollis, C., Mummery, P., Sherratt, M., Thompson, G. & Watts, D.
1/06/11 → 31/05/16
New research reveals how future asthma treatments could improve
1 Media contribution
Knowledge on Asthma Medications Improve Future Treatment
1 item of Media coverage
New understanding of asthma medicines could improve future treatment
27/04/20 → 30/04/20
4 items of Media coverage, 1 Media contribution