Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review

Md Sadique Hussain; Obaid  Afzal; Gaurav Gupta; Ahsas Goel; Waleed Hassan Almalki; Imran Kazmi; Sami I. Alzarea; Abdulmalik Saleh Alfawaz Altamimi; Neelam Kukreti; Amlan Chakraborty; Sachin Kumar Singh; Kamal Dua

doi:10.17179/excli2023-6553

Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review

Md Sadique Hussain, Obaid Afzal, Gaurav Gupta, Ahsas Goel, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Abdulmalik Saleh Alfawaz Altamimi, Neelam Kukreti, Amlan Chakraborty, Sachin Kumar Singh, Kamal Dua

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes optimistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's crucial role in LC.

Original language	English
Pages (from-to)	34-52
Number of pages	19
Journal	EXCLI Journal
Volume	23
DOIs	https://doi.org/10.17179/excli2023-6553
Publication status	Published - 3 Jan 2024

Keywords

Long non-coding RNA
NEAT1
cancer
clinical applications
lung cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.17179/excli2023-6553Licence: CC BY

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title = "Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review",

abstract = "This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes optimistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's crucial role in LC.",

keywords = "Long non-coding RNA, NEAT1, cancer, clinical applications, lung cancer",

author = "Hussain, {Md Sadique} and Obaid Afzal and Gaurav Gupta and Ahsas Goel and Almalki, {Waleed Hassan} and Imran Kazmi and Alzarea, {Sami I.} and Altamimi, {Abdulmalik Saleh Alfawaz} and Neelam Kukreti and Amlan Chakraborty and Singh, {Sachin Kumar} and Kamal Dua",

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month = jan,

day = "3",

doi = "10.17179/excli2023-6553",

language = "English",

volume = "23",

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AU - Hussain, Md Sadique

AU - Afzal, Obaid

AU - Gupta, Gaurav

AU - Goel, Ahsas

AU - Almalki, Waleed Hassan

AU - Kazmi, Imran

AU - Alzarea, Sami I.

AU - Altamimi, Abdulmalik Saleh Alfawaz

AU - Kukreti, Neelam

AU - Chakraborty, Amlan

AU - Singh, Sachin Kumar

AU - Dua, Kamal

PY - 2024/1/3

Y1 - 2024/1/3

N2 - This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes optimistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's crucial role in LC.

AB - This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes optimistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's crucial role in LC.

KW - Long non-coding RNA

KW - NEAT1

KW - cancer

KW - clinical applications

KW - lung cancer

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UR - https://www.mendeley.com/catalogue/9ccca1f1-0ebc-378b-b54d-b3194b54c0d6/

U2 - 10.17179/excli2023-6553

DO - 10.17179/excli2023-6553

M3 - Review article

C2 - 38343745

SN - 1611-2156

VL - 23

SP - 34

EP - 52

JO - EXCLI Journal

JF - EXCLI Journal

ER -

Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review

Abstract

Keywords

UN SDGs

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