Unusual DQA-DR haplotypes in rheumatoid vasculitis

M. C. Hillarby, W. E R Ollier, M. Davis, J. Davidson, P. A. Sanders, D. M. Grennan

    Research output: Contribution to journalArticlepeer-review


    DQA and DQB variants and HLA haplotypes were defined in Caucasian subjects with rheumatoid arthritis (RA), in a rheumatoid subset characterized clinically by extra-articular features of major vasculitis, and in controls. DQ variants were defined using a panel of sequence specific oligonucleotide probes. In RA subjects without extra-articular features the frequency of DQB(*)0301 was significantly increased but this was secondary to the main association with DR4. In rheumatoid vasculitis by contrast, DQB(*)0302 rather than DQB(*)0301 was increased in frequency, in addition to an increase of C4A null alleles. Family studies showed that DR4 negative haplotypes had an increased frequency of unusual DR-DQA combinations as compared to other rheumatoid subsets. These findings are in keeping with the concept that genes within the MHC other than DR4 have a disease-modifying role in rheumatoid subsets. HLA haplotypes were defined in a family where the proband has RA and Felty's syndrome and an affected sister has rheumatoid vasculitis. These siblings share a DR4 bearing haplotype typing for DQB(*)0301, and the sister with rheumatoid vasculitis has a DR4 negative haplotype carrying a C4A null allele and an unusual DR-DQA combination.
    Original languageEnglish
    Pages (from-to)93-96
    Number of pages3
    JournalBritish Journal of Rheumatology
    Issue number2
    Publication statusPublished - 1993


    • HLA-DQA
    • HLA-DQB
    • HLA-DR
    • MHC
    • Rheumatoid arthritis


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