Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

Jason M D Kalapothakis, Yana Berezovskaya, Cleidiane G. Zampronio, Peter A. Faull, Perdita E. Barran, Helen J. Cooper

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The helix-forming character of a model decapeptide, L4PL 4K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics. © 2014 The Royal Society of Chemistry.
    Original languageEnglish
    Pages (from-to)198-200
    Number of pages2
    JournalChemical Communications
    Volume50
    Issue number2
    DOIs
    Publication statusPublished - 7 Jan 2014

    Keywords

    • electron-capture dissociation
    • charged protein cations
    • tryptic peptides
    • in-vacuo
    • spectra
    • ions

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