Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

S. di Giambenedetto; M. Prosperi; I. Fanti; B. Bruzzone; S. Paolucci; G. Penco; G. Meini; A. di Biagio; E. Paolini; V. Micheli; P. Meraviglia; P. Castelli; P. Corsi; A. Gonnelli; M. Fabbiani; M. Zazzi; A. de Luca

Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

S. di Giambenedetto, M. Prosperi, I. Fanti, B. Bruzzone, S. Paolucci, G. Penco, G. Meini, A. di Biagio, E. Paolini, V. Micheli, P. Meraviglia, P. Castelli, P. Corsi, A. Gonnelli, M. Fabbiani, M. Zazzi, A. de Luca

Research output: Contribution to journal › Article › peer-review

Abstract

We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors. © 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.

Original language	English
Pages (from-to)	1352-1355
Number of pages	3
Journal	Clinical Microbiology and Infection
Volume	17
Issue number	9
Publication status	Published - Sept 2011

Keywords

Antiretroviral therapy
Drug resistance mutations
Human immunodeficiency virus-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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di Giambenedetto, S., Prosperi, M., Fanti, I., Bruzzone, B., Paolucci, S., Penco, G., Meini, G., di Biagio, A., Paolini, E., Micheli, V., Meraviglia, P., Castelli, P., Corsi, P., Gonnelli, A., Fabbiani, M., Zazzi, M., & de Luca, A. (2011). Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009. Clinical Microbiology and Infection, 17(9), 1352-1355.

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title = "Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009",

abstract = "We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors. {\textcopyright} 2011 The Authors. Clinical Microbiology and Infection {\textcopyright} 2011 European Society of Clinical Microbiology and Infectious Diseases.",

keywords = "Antiretroviral therapy, Drug resistance mutations, Human immunodeficiency virus-1",

author = "{di Giambenedetto}, S. and M. Prosperi and I. Fanti and B. Bruzzone and S. Paolucci and G. Penco and G. Meini and {di Biagio}, A. and E. Paolini and V. Micheli and P. Meraviglia and P. Castelli and P. Corsi and A. Gonnelli and M. Fabbiani and M. Zazzi and {de Luca}, A.",

year = "2011",

month = sep,

language = "English",

volume = "17",

pages = "1352--1355",

journal = "Clinical Microbiology and Infection",

issn = "1469-0691",

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di Giambenedetto, S, Prosperi, M, Fanti, I, Bruzzone, B, Paolucci, S, Penco, G, Meini, G, di Biagio, A, Paolini, E, Micheli, V, Meraviglia, P, Castelli, P, Corsi, P, Gonnelli, A, Fabbiani, M, Zazzi, M & de Luca, A 2011, 'Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009', Clinical Microbiology and Infection, vol. 17, no. 9, pp. 1352-1355.

TY - JOUR

T1 - Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

AU - di Giambenedetto, S.

AU - Prosperi, M.

AU - Fanti, I.

AU - Bruzzone, B.

AU - Paolucci, S.

AU - Penco, G.

AU - Meini, G.

AU - di Biagio, A.

AU - Paolini, E.

AU - Micheli, V.

AU - Meraviglia, P.

AU - Castelli, P.

AU - Corsi, P.

AU - Gonnelli, A.

AU - Fabbiani, M.

AU - Zazzi, M.

AU - de Luca, A.

PY - 2011/9

Y1 - 2011/9

N2 - We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors. © 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.

AB - We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors. © 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.

KW - Antiretroviral therapy

KW - Drug resistance mutations

KW - Human immunodeficiency virus-1

M3 - Article

SN - 1469-0691

VL - 17

SP - 1352

EP - 1355

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 9

ER -

Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

Abstract

Keywords

UN SDGs

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