Urinary obstruction in prostate cancer patients from the Dutch trial (68 Gy vs. 78 Gy): relationships with local dose, acute effects, and baseline characteristics.

Marcel Van Herk; Wilma D Heemsbergen; Abrahim Al-Mamgani; Marnix G Witte; Marcel van Herk; Floris J Pos; Joos V Lebesque

doi:10.1016/j.ijrobp.2009.07.1680

Urinary obstruction in prostate cancer patients from the Dutch trial (68 Gy vs. 78 Gy): relationships with local dose, acute effects, and baseline characteristics.

Marcel Van Herk, Wilma D Heemsbergen, Abrahim Al-Mamgani, Marnix G Witte, Marcel van Herk, Floris J Pos, Joos V Lebesque

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To investigate the relationship between late urinary obstruction and the details of the dose distribution of irradiated prostate cancer patients, taking into account their baseline symptoms and acute complaints. PATIENTS AND METHODS: We selected patients from the Dutch multicenter trial randomized between 68 Gy and 78 Gy, for whom toxicity data and dose data were available (n = 557). The absolute dose surface parameters of the delineated bladder were calculated. Next, we constructed three-dimensional dose maps of the area around the prostate, providing an approximate identification of the corresponding anatomic locations. The dose difference maps were constructed by subtracting the mean dose maps of the patients with and without late urinary obstruction. Selected local dose points were analyzed using Cox regression analysis. RESULTS: Urinary obstruction was scored for 40 patients, including 19 of 296 patients who received 68-72 Gy and 21 of 261 patients who received 76-78 Gy. A total of 19 events occurred within 2 years after irradiation and 21 events after 2 years. The bladder surface receiving >or=80 Gy predicted (p

Original language	English
Journal	International journal of radiation oncology, biology, physics
Volume	78
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2009.07.1680
Publication status	Published - 1 Sept 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ijrobp.2009.07.1680

Cite this

Van Herk, M., Heemsbergen, W. D., Al-Mamgani, A., Witte, M. G., van Herk, M., Pos, F. J., & Lebesque, J. V. (2010). Urinary obstruction in prostate cancer patients from the Dutch trial (68 Gy vs. 78 Gy): relationships with local dose, acute effects, and baseline characteristics. International journal of radiation oncology, biology, physics, 78(1). https://doi.org/10.1016/j.ijrobp.2009.07.1680

@article{343aa8f528044ffe8f0f6e6613e7f1f6,

title = "Urinary obstruction in prostate cancer patients from the Dutch trial (68 Gy vs. 78 Gy): relationships with local dose, acute effects, and baseline characteristics.",

abstract = "PURPOSE: To investigate the relationship between late urinary obstruction and the details of the dose distribution of irradiated prostate cancer patients, taking into account their baseline symptoms and acute complaints. PATIENTS AND METHODS: We selected patients from the Dutch multicenter trial randomized between 68 Gy and 78 Gy, for whom toxicity data and dose data were available (n = 557). The absolute dose surface parameters of the delineated bladder were calculated. Next, we constructed three-dimensional dose maps of the area around the prostate, providing an approximate identification of the corresponding anatomic locations. The dose difference maps were constructed by subtracting the mean dose maps of the patients with and without late urinary obstruction. Selected local dose points were analyzed using Cox regression analysis. RESULTS: Urinary obstruction was scored for 40 patients, including 19 of 296 patients who received 68-72 Gy and 21 of 261 patients who received 76-78 Gy. A total of 19 events occurred within 2 years after irradiation and 21 events after 2 years. The bladder surface receiving >or=80 Gy predicted (p",

author = "{Van Herk}, Marcel and Heemsbergen, {Wilma D} and Abrahim Al-Mamgani and Witte, {Marnix G} and {van Herk}, Marcel and Pos, {Floris J} and Lebesque, {Joos V}",

year = "2010",

month = sep,

day = "1",

doi = "10.1016/j.ijrobp.2009.07.1680",

language = "English",

volume = "78",

journal = "International journal of radiation oncology, biology, physics",

issn = "0360-3016",

publisher = "Elsevier BV",

number = "1",

}

Van Herk, M, Heemsbergen, WD, Al-Mamgani, A, Witte, MG, van Herk, M, Pos, FJ & Lebesque, JV 2010, 'Urinary obstruction in prostate cancer patients from the Dutch trial (68 Gy vs. 78 Gy): relationships with local dose, acute effects, and baseline characteristics.', International journal of radiation oncology, biology, physics, vol. 78, no. 1. https://doi.org/10.1016/j.ijrobp.2009.07.1680

Urinary obstruction in prostate cancer patients from the Dutch trial (68 Gy vs. 78 Gy): relationships with local dose, acute effects, and baseline characteristics. / Van Herk, Marcel; Heemsbergen, Wilma D; Al-Mamgani, Abrahim et al.
In: International journal of radiation oncology, biology, physics, Vol. 78, No. 1, 01.09.2010.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Urinary obstruction in prostate cancer patients from the Dutch trial (68 Gy vs. 78 Gy): relationships with local dose, acute effects, and baseline characteristics.

AU - Van Herk, Marcel

AU - Heemsbergen, Wilma D

AU - Al-Mamgani, Abrahim

AU - Witte, Marnix G

AU - van Herk, Marcel

AU - Pos, Floris J

AU - Lebesque, Joos V

PY - 2010/9/1

Y1 - 2010/9/1

N2 - PURPOSE: To investigate the relationship between late urinary obstruction and the details of the dose distribution of irradiated prostate cancer patients, taking into account their baseline symptoms and acute complaints. PATIENTS AND METHODS: We selected patients from the Dutch multicenter trial randomized between 68 Gy and 78 Gy, for whom toxicity data and dose data were available (n = 557). The absolute dose surface parameters of the delineated bladder were calculated. Next, we constructed three-dimensional dose maps of the area around the prostate, providing an approximate identification of the corresponding anatomic locations. The dose difference maps were constructed by subtracting the mean dose maps of the patients with and without late urinary obstruction. Selected local dose points were analyzed using Cox regression analysis. RESULTS: Urinary obstruction was scored for 40 patients, including 19 of 296 patients who received 68-72 Gy and 21 of 261 patients who received 76-78 Gy. A total of 19 events occurred within 2 years after irradiation and 21 events after 2 years. The bladder surface receiving >or=80 Gy predicted (p

AB - PURPOSE: To investigate the relationship between late urinary obstruction and the details of the dose distribution of irradiated prostate cancer patients, taking into account their baseline symptoms and acute complaints. PATIENTS AND METHODS: We selected patients from the Dutch multicenter trial randomized between 68 Gy and 78 Gy, for whom toxicity data and dose data were available (n = 557). The absolute dose surface parameters of the delineated bladder were calculated. Next, we constructed three-dimensional dose maps of the area around the prostate, providing an approximate identification of the corresponding anatomic locations. The dose difference maps were constructed by subtracting the mean dose maps of the patients with and without late urinary obstruction. Selected local dose points were analyzed using Cox regression analysis. RESULTS: Urinary obstruction was scored for 40 patients, including 19 of 296 patients who received 68-72 Gy and 21 of 261 patients who received 76-78 Gy. A total of 19 events occurred within 2 years after irradiation and 21 events after 2 years. The bladder surface receiving >or=80 Gy predicted (p

U2 - 10.1016/j.ijrobp.2009.07.1680

DO - 10.1016/j.ijrobp.2009.07.1680

M3 - Article

C2 - 20056354

SN - 0360-3016

VL - 78

JO - International journal of radiation oncology, biology, physics

JF - International journal of radiation oncology, biology, physics

IS - 1

ER -

Urinary obstruction in prostate cancer patients from the Dutch trial (68 Gy vs. 78 Gy): relationships with local dose, acute effects, and baseline characteristics.

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this