Urinary protein selectivity in nephrotic syndrome and pregnancy: resurrection of a biomarker when renal biopsy is contraindicated.

Patrick Hamilton, Jenny Myers, Joanna Gillham, Gwen Ayers, Nina Brown, Michael Venning

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Significant proteinuria in pregnancy can indicate the presence of serious conditions requiring investigation and treatment. The nephrotic syndrome in pregnancy presents a multitude of difficulties and is a relative contraindication of renal biopsy, particularly in the third trimester. We present a case of nephrotic syndrome of unknown cause presenting at 33 weeks of pregnancy. With renal biopsy contraindicated, we used the urine protein selectivity test, a largely discarded test predicting steroid-responsive nephrotic syndrome, to help inform the decision to give steroids. This led to a successful clinical outcome including the avoidance of neonatal ICU care for baby.
    Original languageEnglish
    JournalClinical Kidney Journal
    Volume7
    Issue number6
    DOIs
    Publication statusPublished - Dec 2014

    Keywords

    • biomarker
    • nephrotic syndrome
    • pregnancy
    • protein selectivity
    • renal biopsy

    Fingerprint

    Dive into the research topics of 'Urinary protein selectivity in nephrotic syndrome and pregnancy: resurrection of a biomarker when renal biopsy is contraindicated.'. Together they form a unique fingerprint.

    Cite this