Urocanic acid in the skin: A mixed blessing

Neil K. Gibbs; Mary Norval

doi:10.1038/jid.2010.276

Urocanic acid in the skin: A mixed blessing

Neil K. Gibbs, Mary Norval

Research output: Contribution to journal › Article › peer-review

Abstract

Located in the stratum corneum, urocanic acid is a major epidermal chromophore for UVR. This simple molecule has attracted a great deal of research interest over the past half century, initially as a putative natural sunscreen and later as a mediator of photoimmunosuppression with a consequent role in photocarcinogenesis. For the first time, Barresi and colleagues provide robust evidence for the photoprotective role of endogenous urocanic acid and reopen the debate on the relative beneficial and detrimental properties of this molecule. © 2011 The Society for Investigative Dermatology.

Original language	English
Pages (from-to)	14-17
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	131
Issue number	1
DOIs	https://doi.org/10.1038/jid.2010.276
Publication status	Published - Jan 2011

Access to Document

10.1038/jid.2010.276

Cite this

@article{7c76d981608f4aa9b0f003b07c94cf42,

title = "Urocanic acid in the skin: A mixed blessing",

abstract = "Located in the stratum corneum, urocanic acid is a major epidermal chromophore for UVR. This simple molecule has attracted a great deal of research interest over the past half century, initially as a putative natural sunscreen and later as a mediator of photoimmunosuppression with a consequent role in photocarcinogenesis. For the first time, Barresi and colleagues provide robust evidence for the photoprotective role of endogenous urocanic acid and reopen the debate on the relative beneficial and detrimental properties of this molecule. {\textcopyright} 2011 The Society for Investigative Dermatology.",

author = "Gibbs, {Neil K.} and Mary Norval",

year = "2011",

month = jan,

doi = "10.1038/jid.2010.276",

language = "English",

volume = "131",

pages = "14--17",

journal = "Journal of Investigative Dermatology",

issn = "1523-1747",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Urocanic acid in the skin: A mixed blessing

AU - Gibbs, Neil K.

AU - Norval, Mary

PY - 2011/1

Y1 - 2011/1

N2 - Located in the stratum corneum, urocanic acid is a major epidermal chromophore for UVR. This simple molecule has attracted a great deal of research interest over the past half century, initially as a putative natural sunscreen and later as a mediator of photoimmunosuppression with a consequent role in photocarcinogenesis. For the first time, Barresi and colleagues provide robust evidence for the photoprotective role of endogenous urocanic acid and reopen the debate on the relative beneficial and detrimental properties of this molecule. © 2011 The Society for Investigative Dermatology.

AB - Located in the stratum corneum, urocanic acid is a major epidermal chromophore for UVR. This simple molecule has attracted a great deal of research interest over the past half century, initially as a putative natural sunscreen and later as a mediator of photoimmunosuppression with a consequent role in photocarcinogenesis. For the first time, Barresi and colleagues provide robust evidence for the photoprotective role of endogenous urocanic acid and reopen the debate on the relative beneficial and detrimental properties of this molecule. © 2011 The Society for Investigative Dermatology.

U2 - 10.1038/jid.2010.276

DO - 10.1038/jid.2010.276

M3 - Article

C2 - 21157424

SN - 1523-1747

VL - 131

SP - 14

EP - 17

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 1

ER -

Urocanic acid in the skin: A mixed blessing

Abstract

Access to Document

Fingerprint

Cite this