Urocanic acid in the skin: A mixed blessing

Neil K. Gibbs, Mary Norval

    Research output: Contribution to journalArticlepeer-review


    Located in the stratum corneum, urocanic acid is a major epidermal chromophore for UVR. This simple molecule has attracted a great deal of research interest over the past half century, initially as a putative natural sunscreen and later as a mediator of photoimmunosuppression with a consequent role in photocarcinogenesis. For the first time, Barresi and colleagues provide robust evidence for the photoprotective role of endogenous urocanic acid and reopen the debate on the relative beneficial and detrimental properties of this molecule. © 2011 The Society for Investigative Dermatology.
    Original languageEnglish
    Pages (from-to)14-17
    Number of pages3
    JournalJournal of Investigative Dermatology
    Issue number1
    Publication statusPublished - Jan 2011


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