Urotensin-II system in genetic control of blood pressure and renal function.

Radoslaw Debiec; Paraskevi Christofidou; Matthew Denniff; Lisa D Bloomer; Pawel Bogdanski; Lukasz Wojnar; Katarzyna Musialik; Fadi J Charchar; John R Thompson; Dawn Waterworth; Kijoung Song; Peter Vollenweider; Gerard Waeber; Ewa Zukowska-Szczechowska; Nilesh J Samani; David Lambert; Maciej Tomaszewski

doi:10.1371/journal.pone.0083137

Urotensin-II system in genetic control of blood pressure and renal function.

Radoslaw Debiec, Paraskevi Christofidou, Matthew Denniff, Lisa D Bloomer, Pawel Bogdanski, Lukasz Wojnar, Katarzyna Musialik, Fadi J Charchar, John R Thompson, Dawn Waterworth, Kijoung Song, Peter Vollenweider, Gerard Waeber, Ewa Zukowska-Szczechowska, Nilesh J Samani, David Lambert, Maciej Tomaszewski

Research output: Contribution to journal › Article › peer-review

Abstract

Urotensin-II controls ion/water homeostasis in fish and vascular tone in rodents. We hypothesised that common genetic variants in urotensin-II pathway genes are associated with human blood pressure or renal function. We performed family-based analysis of association between blood pressure, glomerular filtration and genes of the urotensin-II pathway (urotensin-II, urotensin-II related peptide, urotensin-II receptor) saturated with 28 tagging single nucleotide polymorphisms in 2024 individuals from 520 families; followed by an independent replication in 420 families and 7545 unrelated subjects. The expression studies of the urotensin-II pathway were carried out in 97 human kidneys. Phylogenetic evolutionary analysis was conducted in 17 vertebrate species. One single nucleotide polymorphism (rs531485 in urotensin-II gene) was associated with adjusted estimated glomerular filtration rate in the discovery cohort (p = 0.0005). It showed no association with estimated glomerular filtration rate in the combined replication resource of 8724 subjects from 6 populations. Expression of urotensin-II and its receptor showed strong linear correlation (r = 0.86, p

Original language	English
Journal	PLoS ONE
Volume	8
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0083137
Publication status	Published - 2013

Access to Document

10.1371/journal.pone.0083137

Cite this

Debiec, R., Christofidou, P., Denniff, M., Bloomer, L. D., Bogdanski, P., Wojnar, L., Musialik, K., Charchar, F. J., Thompson, J. R., Waterworth, D., Song, K., Vollenweider, P., Waeber, G., Zukowska-Szczechowska, E., Samani, N. J., Lambert, D., & Tomaszewski, M. (2013). Urotensin-II system in genetic control of blood pressure and renal function. PLoS ONE, 8(12). https://doi.org/10.1371/journal.pone.0083137

@article{50957e82d5ad4252b71275d8cd461eb1,

title = "Urotensin-II system in genetic control of blood pressure and renal function.",

abstract = "Urotensin-II controls ion/water homeostasis in fish and vascular tone in rodents. We hypothesised that common genetic variants in urotensin-II pathway genes are associated with human blood pressure or renal function. We performed family-based analysis of association between blood pressure, glomerular filtration and genes of the urotensin-II pathway (urotensin-II, urotensin-II related peptide, urotensin-II receptor) saturated with 28 tagging single nucleotide polymorphisms in 2024 individuals from 520 families; followed by an independent replication in 420 families and 7545 unrelated subjects. The expression studies of the urotensin-II pathway were carried out in 97 human kidneys. Phylogenetic evolutionary analysis was conducted in 17 vertebrate species. One single nucleotide polymorphism (rs531485 in urotensin-II gene) was associated with adjusted estimated glomerular filtration rate in the discovery cohort (p = 0.0005). It showed no association with estimated glomerular filtration rate in the combined replication resource of 8724 subjects from 6 populations. Expression of urotensin-II and its receptor showed strong linear correlation (r = 0.86, p",

author = "Radoslaw Debiec and Paraskevi Christofidou and Matthew Denniff and Bloomer, {Lisa D} and Pawel Bogdanski and Lukasz Wojnar and Katarzyna Musialik and Charchar, {Fadi J} and Thompson, {John R} and Dawn Waterworth and Kijoung Song and Peter Vollenweider and Gerard Waeber and Ewa Zukowska-Szczechowska and Samani, {Nilesh J} and David Lambert and Maciej Tomaszewski",

year = "2013",

doi = "10.1371/journal.pone.0083137",

language = "English",

volume = "8",

journal = "PLoS ONE",

publisher = "Public Library of Science",

number = "12",

}

Debiec, R, Christofidou, P, Denniff, M, Bloomer, LD, Bogdanski, P, Wojnar, L, Musialik, K, Charchar, FJ, Thompson, JR, Waterworth, D, Song, K, Vollenweider, P, Waeber, G, Zukowska-Szczechowska, E, Samani, NJ, Lambert, D & Tomaszewski, M 2013, 'Urotensin-II system in genetic control of blood pressure and renal function.', PLoS ONE, vol. 8, no. 12. https://doi.org/10.1371/journal.pone.0083137

TY - JOUR

T1 - Urotensin-II system in genetic control of blood pressure and renal function.

AU - Debiec, Radoslaw

AU - Christofidou, Paraskevi

AU - Denniff, Matthew

AU - Bloomer, Lisa D

AU - Bogdanski, Pawel

AU - Wojnar, Lukasz

AU - Musialik, Katarzyna

AU - Charchar, Fadi J

AU - Thompson, John R

AU - Waterworth, Dawn

AU - Song, Kijoung

AU - Vollenweider, Peter

AU - Waeber, Gerard

AU - Zukowska-Szczechowska, Ewa

AU - Samani, Nilesh J

AU - Lambert, David

AU - Tomaszewski, Maciej

PY - 2013

Y1 - 2013

N2 - Urotensin-II controls ion/water homeostasis in fish and vascular tone in rodents. We hypothesised that common genetic variants in urotensin-II pathway genes are associated with human blood pressure or renal function. We performed family-based analysis of association between blood pressure, glomerular filtration and genes of the urotensin-II pathway (urotensin-II, urotensin-II related peptide, urotensin-II receptor) saturated with 28 tagging single nucleotide polymorphisms in 2024 individuals from 520 families; followed by an independent replication in 420 families and 7545 unrelated subjects. The expression studies of the urotensin-II pathway were carried out in 97 human kidneys. Phylogenetic evolutionary analysis was conducted in 17 vertebrate species. One single nucleotide polymorphism (rs531485 in urotensin-II gene) was associated with adjusted estimated glomerular filtration rate in the discovery cohort (p = 0.0005). It showed no association with estimated glomerular filtration rate in the combined replication resource of 8724 subjects from 6 populations. Expression of urotensin-II and its receptor showed strong linear correlation (r = 0.86, p

AB - Urotensin-II controls ion/water homeostasis in fish and vascular tone in rodents. We hypothesised that common genetic variants in urotensin-II pathway genes are associated with human blood pressure or renal function. We performed family-based analysis of association between blood pressure, glomerular filtration and genes of the urotensin-II pathway (urotensin-II, urotensin-II related peptide, urotensin-II receptor) saturated with 28 tagging single nucleotide polymorphisms in 2024 individuals from 520 families; followed by an independent replication in 420 families and 7545 unrelated subjects. The expression studies of the urotensin-II pathway were carried out in 97 human kidneys. Phylogenetic evolutionary analysis was conducted in 17 vertebrate species. One single nucleotide polymorphism (rs531485 in urotensin-II gene) was associated with adjusted estimated glomerular filtration rate in the discovery cohort (p = 0.0005). It showed no association with estimated glomerular filtration rate in the combined replication resource of 8724 subjects from 6 populations. Expression of urotensin-II and its receptor showed strong linear correlation (r = 0.86, p

U2 - 10.1371/journal.pone.0083137

DO - 10.1371/journal.pone.0083137

M3 - Article

C2 - 24391740

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 12

ER -

Urotensin-II system in genetic control of blood pressure and renal function.

Abstract

Access to Document

Fingerprint

Cite this