Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

Geraint R. Davies; Richard Brindle; Saye H. Khoo; Leon J. Aarons

doi:10.1128/AAC.00774-05

Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

Geraint R. Davies
, Richard Brindle
, Saye H. Khoo
, Leon J. Aarons

Research output: Contribution to journal › Article › peer-review

Abstract

Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	3154-3156
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00774-05
Publication status	Published - Sept 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1128/AAC.00774-05

Cite this

@article{104061921aeb416b985007bd5620f5e4,

title = "Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment",

abstract = "Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of {"}sterilization{"} in the development of new antituberculosis regimens. Copyright {\textcopyright} 2006, American Society for Microbiology. All Rights Reserved.",

author = "Davies, \{Geraint R.\} and Richard Brindle and Khoo, \{Saye H.\} and Aarons, \{Leon J.\}",

year = "2006",

month = sep,

doi = "10.1128/AAC.00774-05",

language = "English",

volume = "50",

pages = "3154--3156",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

AU - Davies, Geraint R.

AU - Brindle, Richard

AU - Khoo, Saye H.

AU - Aarons, Leon J.

PY - 2006/9

Y1 - 2006/9

N2 - Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

AB - Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

U2 - 10.1128/AAC.00774-05

DO - 10.1128/AAC.00774-05

M3 - Article

SN - 0066-4804

VL - 50

SP - 3154

EP - 3156

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

ER -

Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this