TY - JOUR
T1 - Utility of a simplified [ 18 F] sodium fluoride PET imaging method to quantify bone metabolic flux for a wide range of clinical applications
AU - Puri, Tanuj
AU - Frost, Michelle L.
AU - Moore, Amelia E. B.
AU - Choudhury, Ananya
AU - Vinjamuri, Sobhan
AU - Mahajan, Abhishek
AU - Fynbo, Claire
AU - Vrist, Marie
AU - Theil, Jørn
AU - Kairemo, Kalevi
AU - Wong, James
AU - Zaidi, Habib
AU - Revheim, Mona-Elisabeth
AU - Werner, Thomas J.
AU - Alavi, Abass N.
AU - Cook, Gary
AU - Blake, Glen
N1 - Funding Information:
AC is supported by the National Institute for Health Research (NIHR) Manchester Biomedical Research Centre. The University of Manchester has covered the cost of open access publication associated with this manuscript. Acknowledgments
Funding Information:
AC is supported by the National Institute for Health Research (NIHR) Manchester Biomedical Research Centre. The University of Manchester has covered the cost of open access publication associated with this manuscript.
Publisher Copyright:
Copyright © 2023 Puri, Frost, Moore, Choudhury, Vinjamuri, Mahajan, Fynbo, Vrist, Theil, Kairemo, Wong, Zaidi, Revheim, Werner, Alavi, Cook and Blake.
PY - 2023/9/13
Y1 - 2023/9/13
N2 - We review the rationale, methodology, and clinical utility of quantitative [ 18 F] sodium fluoride ([ 18 F]NaF) positron emission tomography-computed tomography (PET-CT) imaging to measure bone metabolic flux (Ki, also known as bone plasma clearance), a measurement indicative of the local rate of bone formation at the chosen region of interest. We review the bone remodelling cycle and explain what aspects of bone remodelling are addressed by [ 18 F]NaF PET-CT. We explain how the technique works, what measurements are involved, and what makes [ 18 F]NaF PET-CT a useful tool for the study of bone remodelling. We discuss how these measurements can be simplified without loss of accuracy to make the technique more accessible. Finally, we briefly review some key clinical applications and discuss the potential for future developments. We hope that the simplified method described here will assist in promoting the wider use of the technique.
AB - We review the rationale, methodology, and clinical utility of quantitative [ 18 F] sodium fluoride ([ 18 F]NaF) positron emission tomography-computed tomography (PET-CT) imaging to measure bone metabolic flux (Ki, also known as bone plasma clearance), a measurement indicative of the local rate of bone formation at the chosen region of interest. We review the bone remodelling cycle and explain what aspects of bone remodelling are addressed by [ 18 F]NaF PET-CT. We explain how the technique works, what measurements are involved, and what makes [ 18 F]NaF PET-CT a useful tool for the study of bone remodelling. We discuss how these measurements can be simplified without loss of accuracy to make the technique more accessible. Finally, we briefly review some key clinical applications and discuss the potential for future developments. We hope that the simplified method described here will assist in promoting the wider use of the technique.
KW - K
KW - PET-CT
KW - [ F] sodium fluoride
KW - [ F]NaF
KW - bone metabolic flux
KW - clinical applications
KW - future developments
KW - quantitative measurement of bone
KW - Sodium Fluoride
KW - Bone and Bones/diagnostic imaging
KW - Humans
KW - Bone Neoplasms
KW - Positron Emission Tomography Computed Tomography/methods
KW - Positron-Emission Tomography/methods
UR - https://www.frontiersin.org/articles/10.3389/fendo.2023.1236881/abstract
UR - http://www.scopus.com/inward/record.url?scp=85173048500&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/ce82e2ad-a864-353c-9d1a-3443d1c4d124/
U2 - 10.3389/fendo.2023.1236881
DO - 10.3389/fendo.2023.1236881
M3 - Article
C2 - 37780613
SN - 1664-2392
VL - 14
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 1236881
ER -