Utilization of SABRE-Derived Hyperpolarization To Detect Low-Concentration Analytes via 1D and 2D NMR Methods

L S Lloyd, R W Adams, M Bernstein, S Coombes, S B Duckett, G G R Green, R J Lewis, R E Mewis, C J Sleigh

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The characterization of materials by the inherently insensitive method of NMR spectroscopy plays a vital role in chemistry. Increasingly, hyperpolarization is being used to address the sensitivity limitation. Here, by reference to quinoline, we illustrate that the SABRE hyperpolarization technique, which uses para-hydrogen as the source of polarization, enables the rapid completion of a range of NMR measurements. These include the collection of C-13, C-13{H-1}, and NOE data in addition to more complex 2D COSY, ultrafast 2D COSY and 2D HMBC spectra. The observations are made possible by the use of a flow probe and external sample preparation cell to re-hyperpolarize the substrate between transients, allowing repeat measurements to be made within seconds. The potential benefit of the combination of SABRE and 2D NMR methods for rapid characterization of low-concentration analytes is therefore established.
    Original languageEnglish
    Pages (from-to)12904-12907
    Number of pages4
    JournalJournal of the American Chemical Society
    Volume134
    Issue number31
    DOIs
    Publication statusPublished - 2012

    Keywords

    • pulsed-field gradients
    • para-hydrogen
    • polarization transfer
    • nobel lecture
    • single-scan
    • spectroscopy
    • enhancement
    • principles
    • complexes
    • catalysts

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