Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray study

Fiona Blackhall; Fiona H. Blackhall; Dennis A. Wigle; Igor Jurisica; Melania Pintilie; Ni Liu; Gail Darling; Michael R. Johnston; Shaf Keshavjee; Thomas Waddell; Timothy Winton; Frances A. Shepherd; Ming Sound Tsao

doi:10.1016/j.lungcan.2004.04.002

Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray study

Fiona Blackhall, Fiona H. Blackhall, Dennis A. Wigle, Igor Jurisica, Melania Pintilie, Ni Liu, Gail Darling, Michael R. Johnston, Shaf Keshavjee, Thomas Waddell, Timothy Winton, Frances A. Shepherd, Ming Sound Tsao

Research output: Contribution to journal › Article › peer-review

Abstract

We previously reported that our cDNA microarray analysis of primary non-small cell lung carcinoma (NSCLC) could predict for patients at increased risk of cancer recurrence. From the result of this analysis, we selected 11 genes that were considered candidate prognostic marker genes and used the realtime reverse transcription polymerase chain reaction (RT-PCR) to investigate their expression in the same set of NSCLC cases used in the microarray study. Cluster analysis of the realtime RT-PCR data separated these patients into two groups with significantly different disease-free survivals (log-rank test, P

Original language	English
Pages (from-to)	197-204
Number of pages	7
Journal	Lung Cancer
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/j.lungcan.2004.04.002
Publication status	Published - Nov 2004

Keywords

Microarray
Prognostic markers, lung cancer
Realtime RT-PCR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.lungcan.2004.04.002

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Blackhall, F., Blackhall, F. H., Wigle, D. A., Jurisica, I., Pintilie, M., Liu, N., Darling, G., Johnston, M. R., Keshavjee, S., Waddell, T., Winton, T., Shepherd, F. A., & Tsao, M. S. (2004). Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray study. Lung Cancer, 46(2), 197-204. https://doi.org/10.1016/j.lungcan.2004.04.002

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title = "Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray study",

abstract = "We previously reported that our cDNA microarray analysis of primary non-small cell lung carcinoma (NSCLC) could predict for patients at increased risk of cancer recurrence. From the result of this analysis, we selected 11 genes that were considered candidate prognostic marker genes and used the realtime reverse transcription polymerase chain reaction (RT-PCR) to investigate their expression in the same set of NSCLC cases used in the microarray study. Cluster analysis of the realtime RT-PCR data separated these patients into two groups with significantly different disease-free survivals (log-rank test, P",

keywords = "Microarray, Prognostic markers, lung cancer, Realtime RT-PCR",

author = "Fiona Blackhall and Blackhall, {Fiona H.} and Wigle, {Dennis A.} and Igor Jurisica and Melania Pintilie and Ni Liu and Gail Darling and Johnston, {Michael R.} and Shaf Keshavjee and Thomas Waddell and Timothy Winton and Shepherd, {Frances A.} and Tsao, {Ming Sound}",

year = "2004",

month = nov,

doi = "10.1016/j.lungcan.2004.04.002",

language = "English",

volume = "46",

pages = "197--204",

journal = "Lung Cancer",

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T1 - Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray study

AU - Blackhall, Fiona

AU - Blackhall, Fiona H.

AU - Wigle, Dennis A.

AU - Jurisica, Igor

AU - Pintilie, Melania

AU - Liu, Ni

AU - Darling, Gail

AU - Johnston, Michael R.

AU - Keshavjee, Shaf

AU - Waddell, Thomas

AU - Winton, Timothy

AU - Shepherd, Frances A.

AU - Tsao, Ming Sound

PY - 2004/11

Y1 - 2004/11

N2 - We previously reported that our cDNA microarray analysis of primary non-small cell lung carcinoma (NSCLC) could predict for patients at increased risk of cancer recurrence. From the result of this analysis, we selected 11 genes that were considered candidate prognostic marker genes and used the realtime reverse transcription polymerase chain reaction (RT-PCR) to investigate their expression in the same set of NSCLC cases used in the microarray study. Cluster analysis of the realtime RT-PCR data separated these patients into two groups with significantly different disease-free survivals (log-rank test, P

AB - We previously reported that our cDNA microarray analysis of primary non-small cell lung carcinoma (NSCLC) could predict for patients at increased risk of cancer recurrence. From the result of this analysis, we selected 11 genes that were considered candidate prognostic marker genes and used the realtime reverse transcription polymerase chain reaction (RT-PCR) to investigate their expression in the same set of NSCLC cases used in the microarray study. Cluster analysis of the realtime RT-PCR data separated these patients into two groups with significantly different disease-free survivals (log-rank test, P

KW - Microarray

KW - Prognostic markers, lung cancer

KW - Realtime RT-PCR

U2 - 10.1016/j.lungcan.2004.04.002

DO - 10.1016/j.lungcan.2004.04.002

M3 - Article

SN - 0169-5002

VL - 46

SP - 197

EP - 204

JO - Lung Cancer

JF - Lung Cancer

IS - 2

ER -

Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray study

Abstract

Keywords

UN SDGs

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