TY - JOUR
T1 - Validation of a Novel Radiographic Scoring System for Calcinosis Affecting the Hands of Patients with Systemic Sclerosis.
AU - Chung, Lorinda
AU - Valenzuela, Antonia
AU - Fiorentino, David
AU - Stevens, Kathryn
AU - Li, Shufeng
AU - Harris, Jonathan
AU - Hutchinson, Charles
AU - Assassi, Shervin
AU - Beretta, Lorenzo
AU - Lakshminarayanan, Santhanam
AU - Rodriguez-Reyna, Tatiana S
AU - Denton, Christopher P
AU - Taillefer, Rebecca G
AU - Herrick, Ariane L
AU - Baron, Murray
PY - 2015
Y1 - 2015
N2 - Objective: There are currently no validated outcome measures to assess calcinosis severity in systemic sclerosis (SSc). We sought to develop and validate a novel radiographic scoring system for calcinosis affecting the hands of SSc patients for potential use in future clinical trials. Methods: Following a 1-hour teleconference training session, 12 investigators (8 rheumatologists, 1 dermatologist, 3 radiologists) scored 12 hand radiographs in random order using two scoring systems (termed "simple" and "complex"), and re-scored 2 randomly assigned radiographs after a minimum of 24 hours. Inter-rater and intra-rater reliability were assessed using a weighted kappa coefficient for the simple system, and intraclass correlation coefficient (ICC) for the complex system (ICC <0.4 poor, 0.4-0.7 moderate, > 0.7 excellent). Results: Mean time to complete the complex scoring system was significantly longer than the simple scoring system (4.0 vs. 0.4 minutes, p
AB - Objective: There are currently no validated outcome measures to assess calcinosis severity in systemic sclerosis (SSc). We sought to develop and validate a novel radiographic scoring system for calcinosis affecting the hands of SSc patients for potential use in future clinical trials. Methods: Following a 1-hour teleconference training session, 12 investigators (8 rheumatologists, 1 dermatologist, 3 radiologists) scored 12 hand radiographs in random order using two scoring systems (termed "simple" and "complex"), and re-scored 2 randomly assigned radiographs after a minimum of 24 hours. Inter-rater and intra-rater reliability were assessed using a weighted kappa coefficient for the simple system, and intraclass correlation coefficient (ICC) for the complex system (ICC <0.4 poor, 0.4-0.7 moderate, > 0.7 excellent). Results: Mean time to complete the complex scoring system was significantly longer than the simple scoring system (4.0 vs. 0.4 minutes, p
U2 - 10.1002/acr.22434
DO - 10.1002/acr.22434
M3 - Article
C2 - 25155948
SN - 2151-4658
VL - 67
SP - 425
EP - 430
JO - Arthritis Care & Research
JF - Arthritis Care & Research
IS - 3
ER -