Vanadate as a futile, superoxide ion-producing substrate of trypanothione reductase from Trypanosoma cruzi

Mohammed Omar Faruk Khan; Seheli Parveen; Gavin Malcolm Seddon; Kenneth Thomas Douglas

doi:10.1246/cl.2005.1558

Vanadate as a futile, superoxide ion-producing substrate of trypanothione reductase from Trypanosoma cruzi

Mohammed Omar Faruk Khan, Seheli Parveen, Gavin Malcolm Seddon, Kenneth Thomas Douglas^*

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Abstract

Recombinant Trypanosoma cruzi trypanothione reductase can oxidize NADPH in a futile cycle in the presence of vanadate ion as a result of the generation of reactive oxygen and other radical species from the active site dithiol and the NADPH. This process is inhibited by competitive inhibitors of trypanothione reductase catalyzed reduction of trypanothione disulfide.

Original language	English
Pages (from-to)	1558-1559
Number of pages	2
Journal	Chemistry Letters
Volume	34
Issue number	11
Early online date	15 Oct 2005
DOIs	https://doi.org/10.1246/cl.2005.1558
Publication status	Published - 5 Nov 2005

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title = "Vanadate as a futile, superoxide ion-producing substrate of trypanothione reductase from Trypanosoma cruzi",

abstract = "Recombinant Trypanosoma cruzi trypanothione reductase can oxidize NADPH in a futile cycle in the presence of vanadate ion as a result of the generation of reactive oxygen and other radical species from the active site dithiol and the NADPH. This process is inhibited by competitive inhibitors of trypanothione reductase catalyzed reduction of trypanothione disulfide.",

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AU - Parveen, Seheli

AU - Seddon, Gavin Malcolm

AU - Douglas, Kenneth Thomas

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N2 - Recombinant Trypanosoma cruzi trypanothione reductase can oxidize NADPH in a futile cycle in the presence of vanadate ion as a result of the generation of reactive oxygen and other radical species from the active site dithiol and the NADPH. This process is inhibited by competitive inhibitors of trypanothione reductase catalyzed reduction of trypanothione disulfide.

AB - Recombinant Trypanosoma cruzi trypanothione reductase can oxidize NADPH in a futile cycle in the presence of vanadate ion as a result of the generation of reactive oxygen and other radical species from the active site dithiol and the NADPH. This process is inhibited by competitive inhibitors of trypanothione reductase catalyzed reduction of trypanothione disulfide.

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JO - Chemistry Letters

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Vanadate as a futile, superoxide ion-producing substrate of trypanothione reductase from Trypanosoma cruzi

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