Variability and regulation of O6-alkylguanine-DNA alkyltransferase

Geoffrey P. Margison; Andrew C. Povey; Bernd Kaina; Mauro F. Santibáñez Koref

doi:10.1093/carcin/bgg005

Variability and regulation of O6-alkylguanine-DNA alkyltransferase

Geoffrey P. Margison, Andrew C. Povey, Bernd Kaina, Mauro F. Santibáñez Koref

Research output: Contribution to journal › Article › peer-review

Abstract

O6-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

Original language	English
Pages (from-to)	625-635
Number of pages	10
Journal	Carcinogenesis
Volume	24
Issue number	4
DOIs	https://doi.org/10.1093/carcin/bgg005
Publication status	Published - 1 Apr 2003

Keywords

Alkylating Agents
Alkylation
Amino Acid Sequence
chemistry
Chromatin
Dna
Human
metabolism
Molecular Sequence Data
O(6)-Methylguanine-DNA Methyltransferase
Phosphorylation
physiology
Promoter Regions (Genetics)
Research
Role
Sequence Homology,Amino Acid
Support,Non-U.S.Gov't
Transcription Factors
chemistry: Chromatin
metabolism: DNA
Humans
chemistry: O(6)-Methylguanine-DNA Methyltransferase
Research Support, Non-U.S. Gov't
Sequence Homology, Amino Acid
metabolism: Transcription Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Variability and regulation of O6-alkylguanine-DNA alkyltransferase",

abstract = "O6-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.",

keywords = "Alkylating Agents, Alkylation, Amino Acid Sequence, chemistry, Chromatin, Dna, Human, metabolism, Molecular Sequence Data, O(6)-Methylguanine-DNA Methyltransferase, Phosphorylation, physiology, Promoter Regions (Genetics), Research, Role, Sequence Homology,Amino Acid, Support,Non-U.S.Gov't, Transcription Factors, chemistry: Chromatin, metabolism: DNA, Humans, chemistry: O(6)-Methylguanine-DNA Methyltransferase, Research Support, Non-U.S. Gov't, Sequence Homology, Amino Acid, metabolism: Transcription Factors",

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language = "English",

volume = "24",

pages = "625--635",

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AU - Margison, Geoffrey P.

AU - Povey, Andrew C.

AU - Kaina, Bernd

AU - Santibáñez Koref, Mauro F.

N1 - UI - 22612553DA - 20030502IS - 0143-3334LA - engPT - Journal ArticlePT - ReviewPT - Review, AcademicRN - 0 (Chromatin)RN - 0 (Transcription Factors)RN - 9007-49-2 (DNA)RN - EC 2.1.1.63 (O(6)-Methylguanine-DNA Methyltransferase)SB - IM

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N2 - O6-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

AB - O6-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

KW - Alkylating Agents

KW - Alkylation

KW - Amino Acid Sequence

KW - chemistry

KW - Chromatin

KW - Dna

KW - Human

KW - metabolism

KW - Molecular Sequence Data

KW - O(6)-Methylguanine-DNA Methyltransferase

KW - Phosphorylation

KW - physiology

KW - Promoter Regions (Genetics)

KW - Research

KW - Role

KW - Sequence Homology,Amino Acid

KW - Support,Non-U.S.Gov't

KW - Transcription Factors

KW - chemistry: Chromatin

KW - metabolism: DNA

KW - Humans

KW - chemistry: O(6)-Methylguanine-DNA Methyltransferase

KW - Research Support, Non-U.S. Gov't

KW - Sequence Homology, Amino Acid

KW - metabolism: Transcription Factors

U2 - 10.1093/carcin/bgg005

DO - 10.1093/carcin/bgg005

M3 - Article

SN - 0143-3334

VL - 24

SP - 625

EP - 635

JO - Carcinogenesis

JF - Carcinogenesis

IS - 4

ER -

Variability and regulation of O6-alkylguanine-DNA alkyltransferase

Abstract

Keywords

UN SDGs

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