Variability and regulation of O6-alkylguanine-DNA alkyltransferase

Geoffrey P. Margison, Andrew C. Povey, Bernd Kaina, Mauro F. Santibáñez Koref

    Research output: Contribution to journalArticlepeer-review


    O6-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.
    Original languageEnglish
    Pages (from-to)625-635
    Number of pages10
    Issue number4
    Publication statusPublished - 1 Apr 2003


    • Alkylating Agents
    • Alkylation
    • Amino Acid Sequence
    • chemistry
    • Chromatin
    • Dna
    • Human
    • metabolism
    • Molecular Sequence Data
    • O(6)-Methylguanine-DNA Methyltransferase
    • Phosphorylation
    • physiology
    • Promoter Regions (Genetics)
    • Research
    • Role
    • Sequence Homology,Amino Acid
    • Support,Non-U.S.Gov't
    • Transcription Factors
    • chemistry: Chromatin
    • metabolism: DNA
    • Humans
    • chemistry: O(6)-Methylguanine-DNA Methyltransferase
    • Research Support, Non-U.S. Gov't
    • Sequence Homology, Amino Acid
    • metabolism: Transcription Factors


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