Variability in parathyroid hormone assays confounds clinical practice in chronic kidney disease patients

Helen Eddington; Julie E. Hudson; Robert L. Oliver; William D. Fraser; Alastair J. Hutchison; Philip A. Kalra

doi:10.1177/0004563213491236

Variability in parathyroid hormone assays confounds clinical practice in chronic kidney disease patients

Helen Eddington, Julie E. Hudson, Robert L. Oliver, William D. Fraser, Alastair J. Hutchison, Philip A. Kalra

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Intact parathyroid hormone (iPTH) measurements are used to guide therapy in renal patients, but variability in results can occur depending on the assay used. This study has investigated iPTH assay variation in North West England and paired data with regional audit data to determine clinical relevance of assay variability. Methods: Thirty-seven haemodialysis patients had blood taken (EDTA plasma, and serum), and samples were processed at 17 laboratories that analyse iPTH for North West dialysis patients. Correction factors were calculated and applied to the iPTH assay results to enable direct comparisons. These correction factors were also applied to Regional Audit data to determine if iPTH assay variability explains the variation in unit performance in achieving PTH targets. Results: The iPTH results from the 37 patients were significantly different when either analysed by different assays and/or different laboratories (P

Original language	English
Pages (from-to)	228-236
Number of pages	8
Journal	Annals of Clinical Biochemistry
Volume	51
Issue number	2
DOIs	https://doi.org/10.1177/0004563213491236
Publication status	Published - 2014

Keywords

chronic kidney disease
clinical studies
haemodialysis
parathyroid hormone
PTH assay
Renal disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Variability in parathyroid hormone assays confounds clinical practice in chronic kidney disease patients",

abstract = "Background: Intact parathyroid hormone (iPTH) measurements are used to guide therapy in renal patients, but variability in results can occur depending on the assay used. This study has investigated iPTH assay variation in North West England and paired data with regional audit data to determine clinical relevance of assay variability. Methods: Thirty-seven haemodialysis patients had blood taken (EDTA plasma, and serum), and samples were processed at 17 laboratories that analyse iPTH for North West dialysis patients. Correction factors were calculated and applied to the iPTH assay results to enable direct comparisons. These correction factors were also applied to Regional Audit data to determine if iPTH assay variability explains the variation in unit performance in achieving PTH targets. Results: The iPTH results from the 37 patients were significantly different when either analysed by different assays and/or different laboratories (P",

keywords = "chronic kidney disease, clinical studies, haemodialysis, parathyroid hormone, PTH assay, Renal disease",

author = "Helen Eddington and Hudson, {Julie E.} and Oliver, {Robert L.} and Fraser, {William D.} and Hutchison, {Alastair J.} and Kalra, {Philip A.}",

year = "2014",

doi = "10.1177/0004563213491236",

language = "English",

volume = "51",

pages = "228--236",

journal = "Annals of Clinical Biochemistry",

issn = "1758-1001",

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T1 - Variability in parathyroid hormone assays confounds clinical practice in chronic kidney disease patients

AU - Eddington, Helen

AU - Hudson, Julie E.

AU - Oliver, Robert L.

AU - Fraser, William D.

AU - Hutchison, Alastair J.

AU - Kalra, Philip A.

PY - 2014

Y1 - 2014

N2 - Background: Intact parathyroid hormone (iPTH) measurements are used to guide therapy in renal patients, but variability in results can occur depending on the assay used. This study has investigated iPTH assay variation in North West England and paired data with regional audit data to determine clinical relevance of assay variability. Methods: Thirty-seven haemodialysis patients had blood taken (EDTA plasma, and serum), and samples were processed at 17 laboratories that analyse iPTH for North West dialysis patients. Correction factors were calculated and applied to the iPTH assay results to enable direct comparisons. These correction factors were also applied to Regional Audit data to determine if iPTH assay variability explains the variation in unit performance in achieving PTH targets. Results: The iPTH results from the 37 patients were significantly different when either analysed by different assays and/or different laboratories (P

AB - Background: Intact parathyroid hormone (iPTH) measurements are used to guide therapy in renal patients, but variability in results can occur depending on the assay used. This study has investigated iPTH assay variation in North West England and paired data with regional audit data to determine clinical relevance of assay variability. Methods: Thirty-seven haemodialysis patients had blood taken (EDTA plasma, and serum), and samples were processed at 17 laboratories that analyse iPTH for North West dialysis patients. Correction factors were calculated and applied to the iPTH assay results to enable direct comparisons. These correction factors were also applied to Regional Audit data to determine if iPTH assay variability explains the variation in unit performance in achieving PTH targets. Results: The iPTH results from the 37 patients were significantly different when either analysed by different assays and/or different laboratories (P

KW - chronic kidney disease

KW - clinical studies

KW - haemodialysis

KW - parathyroid hormone

KW - PTH assay

KW - Renal disease

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DO - 10.1177/0004563213491236

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JO - Annals of Clinical Biochemistry

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Variability in parathyroid hormone assays confounds clinical practice in chronic kidney disease patients

Abstract

Keywords

UN SDGs

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