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Abstract
Aims
The NHS Diabetes Prevention Programme (DPP) is a behaviour-change programme aimed at adults diagnosed with Non-Diabetic Hyperglycaemia (NDH), who are at higher risk of developing Type 2 Diabetes Mellitus (Diabetes). This paper explores the heterogeneity in effectiveness of the DPP by age, sex, BMI, and practice location deprivation (IMD).
Methods
Matched cohort analysis with random-effects parametric survival models, evaluating the association between referral to the DPP and conversion to diabetes, with interactions fitted for age, sex, BMI and IMD.
Results
18,470 patients referred to the programme were matched to 51,331 controls. None of the interactions of patient characteristics with referral were statistically significant. For women, the difference in the HR of conversion to diabetes, compared to men was HR=0.94 (95%CI: 0.81, 1.08, p=0.38); For those aged [18-34],HR=0.79 (95%CI: 0.34,1.84,p=0.58) and aged [75-84] HR=0.86 (95%CI:0.66,1.12, p=0.26) compared to those aged [55-64].
The HR for conversion was 0.88 (95%CI:0.62,1.26, p=0.49) for those with a BMI ≥(25-29.9) kg/m2 and HR=0.76 (95%CI:0.54,1.06, p=0.10) in those with a BMI ≥ 30 kg/m2 compared to BMI<25kg/m2. Finally, for the most deprived IMD quintile, compared to the least deprived, the difference in the conversion was HR=1.31 (95%CI: 0.98, 1.73, p=0.06)
Conclusions
The DPP was effective in reducing conversion rates from NDH to diabetes as shown in our previous study results. The intervention appeared to be similarly effective by age, sex, BMI and deprivation.
The NHS Diabetes Prevention Programme (DPP) is a behaviour-change programme aimed at adults diagnosed with Non-Diabetic Hyperglycaemia (NDH), who are at higher risk of developing Type 2 Diabetes Mellitus (Diabetes). This paper explores the heterogeneity in effectiveness of the DPP by age, sex, BMI, and practice location deprivation (IMD).
Methods
Matched cohort analysis with random-effects parametric survival models, evaluating the association between referral to the DPP and conversion to diabetes, with interactions fitted for age, sex, BMI and IMD.
Results
18,470 patients referred to the programme were matched to 51,331 controls. None of the interactions of patient characteristics with referral were statistically significant. For women, the difference in the HR of conversion to diabetes, compared to men was HR=0.94 (95%CI: 0.81, 1.08, p=0.38); For those aged [18-34],HR=0.79 (95%CI: 0.34,1.84,p=0.58) and aged [75-84] HR=0.86 (95%CI:0.66,1.12, p=0.26) compared to those aged [55-64].
The HR for conversion was 0.88 (95%CI:0.62,1.26, p=0.49) for those with a BMI ≥(25-29.9) kg/m2 and HR=0.76 (95%CI:0.54,1.06, p=0.10) in those with a BMI ≥ 30 kg/m2 compared to BMI<25kg/m2. Finally, for the most deprived IMD quintile, compared to the least deprived, the difference in the conversion was HR=1.31 (95%CI: 0.98, 1.73, p=0.06)
Conclusions
The DPP was effective in reducing conversion rates from NDH to diabetes as shown in our previous study results. The intervention appeared to be similarly effective by age, sex, BMI and deprivation.
| Original language | English |
|---|---|
| Journal | Diabetic Medicine |
| Publication status | Accepted/In press - 23 Mar 2025 |
Keywords
- Diabetic Medicine
- Non-diabetic hyperglycaemia
- NHS Diabetes Prevention Programme
- Electronic Health records
- CPRD
Embargoed Document
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Dive into the research topics of 'Variation in effectiveness of the NHS Diabetes Prevention Programme in people diagnosed with Non-Diabetic Hyperglycaemia by age, sex, BMI and deprivation: a matched cohort analysis of 69,801 people'. Together they form a unique fingerprint.Projects
- 1 Finished
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Evaluating the NHS Diabetes Prevention Programme (NHS DPP): The DIPLOMA Research Programme (Diabetes Prevention - Long Term Multimethod Assessment).
Sutton, M. (PI), Bower, P. (CoI), Chandola, T. (CoI), Cotterill, S. (CoI), French, D. (CoI), Kontopantelis, E. (CoI), Meacock, R. (CoI), Reeves, D. (CoI), Sanders, C. (CoI), Whittaker, W. (CoI) & Wilson, P. (CoI)
1/04/17 → 31/03/21
Project: Research