Abstract
Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow-derived hu man adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and proliferation. VEGF-A binds to both PDGFŔ and PDGFRβ and induces tyrosine phosphorylation that, when inhibited, results in attenuation of VEGF-A-induced MSC migration and proliferation. This mechanism was also shown to mediate human dermal fibroblast (HDF) migration. VEGF-A/PDGFR signaling has the potential to regulate vascular cell recruitment and proliferation during tissue regeneration and disease. © The Rockefeller University Press.
Original language | English |
---|---|
Pages (from-to) | 489-500 |
Number of pages | 11 |
Journal | Journal of Cell Biology |
Volume | 177 |
Issue number | 3 |
DOIs | |
Publication status | Published - 7 May 2007 |