Vascular endothelial growth factor can signal through platelet-derived growth factor receptors

Stephen G. Ball, C. Adrian Shuttleworth, Cay M. Kielty

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow-derived hu man adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and proliferation. VEGF-A binds to both PDGFŔ and PDGFRβ and induces tyrosine phosphorylation that, when inhibited, results in attenuation of VEGF-A-induced MSC migration and proliferation. This mechanism was also shown to mediate human dermal fibroblast (HDF) migration. VEGF-A/PDGFR signaling has the potential to regulate vascular cell recruitment and proliferation during tissue regeneration and disease. © The Rockefeller University Press.
    Original languageEnglish
    Pages (from-to)489-500
    Number of pages11
    JournalJournal of Cell Biology
    Volume177
    Issue number3
    DOIs
    Publication statusPublished - 7 May 2007

    Fingerprint

    Dive into the research topics of 'Vascular endothelial growth factor can signal through platelet-derived growth factor receptors'. Together they form a unique fingerprint.

    Cite this