Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy

S. E. Duff, C. Li, M. Jeziorska, S. Kumar, M. P. Saunders, D. Sherlock, S. T. O'Dwyer, G. C. Jayson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Vascular endothelial growth factor-C (VEGF-C) and VEGF-D are members of the VEGF family of cytokines and have angiogenic and lymphangiogenic actions. In gastric adenocarcinoma, VEGF-C mRNA and tissue protein expression correlate with lymphatic invasion, lymph node metastasis and in some reports, venous invasion and reduced 5-year survival. Patients with gastric adenocarcinomas containing high levels of VEGF-C expression have significantly reduced 5-year survival rates, and VEGF-C expression is an independent prognostic risk factor for death. The role of VEGF-C in oesophageal squamous and colorectal cancer and VEGF-D in colorectal cancer is not clear, with conflicting reports in the published literature. In order to exploit potential therapeutic applications, further research is necessary to define the precise roles of these cytokines in health and disease. © 2003 Cancer Research UK.
    Original languageEnglish
    Pages (from-to)426-430
    Number of pages4
    JournalBritish Journal of Cancer
    Volume89
    Issue number3
    DOIs
    Publication statusPublished - 4 Aug 2003

    Keywords

    • Endothelial growth factors
    • Gastrointestinal neoplasms
    • Lymphangiogenesis
    • Lymphatic system

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