TY - JOUR
T1 - Vascular TRP channels: Performing under pressure and going with the flow
AU - Hill-Eubanks, David C.
AU - Gonzales, Albert L.
AU - Sonkusare, Swapnil K.
AU - Nelson, Mark T.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Endothelial cells and smooth muscle cells of resistance arteries mediate opposing responses to mechanical forces acting on the vasculature, promoting dilation in response to flow and constriction in response to pressure, respectively. In this review, we explore the role of TRP channels, particularly endothelial TRPV4 and smooth muscle TRPC6 and TRPM4 channels, in vascular mechanosensing circuits, placing their putative mechanosensitivity in context with other proposed upstream and downstream signaling pathways. © 2014 Int. Union Physiol. Sci./Am. Physiol. Soc.
AB - Endothelial cells and smooth muscle cells of resistance arteries mediate opposing responses to mechanical forces acting on the vasculature, promoting dilation in response to flow and constriction in response to pressure, respectively. In this review, we explore the role of TRP channels, particularly endothelial TRPV4 and smooth muscle TRPC6 and TRPM4 channels, in vascular mechanosensing circuits, placing their putative mechanosensitivity in context with other proposed upstream and downstream signaling pathways. © 2014 Int. Union Physiol. Sci./Am. Physiol. Soc.
U2 - 10.1152/physiol.00009.2014
DO - 10.1152/physiol.00009.2014
M3 - Article
SN - 1548-9213
VL - 29
SP - 343
EP - 360
JO - Physiology
JF - Physiology
IS - 5
ER -