Vasoactive effects of neurokinin B on human blood vessels

Mark Wareing, Hina Bhatti, Maureen O'Hara, Louise Kenny, Averil Y. Warren, Michael J. Taggart, Philip N. Baker

    Research output: Contribution to journalArticlepeer-review

    Abstract

    OBJECTIVES: Preeclampsia (PE) is a multisystem disease unique to human pregnancy. Abnormal placentation results in placental hypoperfusion leading to the secretion of a factor(s) by the placenta. Our aim was to investigate whether neurokinin B (NKB) is the circulating factor associated with PE. STUDY DESIGN: Vascular effects of NKB were assessed in blood vessels dissected from myometrial and omental biopsy specimens obtained at caesarean section from normal pregnant women (n = 26) or in mesenteric blood vessels obtained from nonpregnant female Wistar rats (n = 4). RESULTS: Incubation with NKB did not alter endothelial-dependent relaxation of omental or myometrial arteries. NKB produced a dose-dependent relaxation in preconstricted omental arteries and veins. NKB did not affect vasoactive responsiveness of rat mesenteric arteries. CONCLUSION: We conclude from these observations that NKB is not the circulating factor associated with increased vascular resistance in PE.
    Original languageEnglish
    Pages (from-to)196-202
    Number of pages6
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume188
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2003

    Keywords

    • Circulating factor
    • Human blood vessels
    • Preeclampsia

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