Vasoactive effects of neurokinin B on human blood vessels

Mark Wareing; Hina Bhatti; Maureen O'Hara; Louise Kenny; Averil Y. Warren; Michael J. Taggart; Philip N. Baker

doi:10.1067/mob.2003.114

Vasoactive effects of neurokinin B on human blood vessels

Mark Wareing, Hina Bhatti, Maureen O'Hara, Louise Kenny, Averil Y. Warren, Michael J. Taggart, Philip N. Baker

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: Preeclampsia (PE) is a multisystem disease unique to human pregnancy. Abnormal placentation results in placental hypoperfusion leading to the secretion of a factor(s) by the placenta. Our aim was to investigate whether neurokinin B (NKB) is the circulating factor associated with PE. STUDY DESIGN: Vascular effects of NKB were assessed in blood vessels dissected from myometrial and omental biopsy specimens obtained at caesarean section from normal pregnant women (n = 26) or in mesenteric blood vessels obtained from nonpregnant female Wistar rats (n = 4). RESULTS: Incubation with NKB did not alter endothelial-dependent relaxation of omental or myometrial arteries. NKB produced a dose-dependent relaxation in preconstricted omental arteries and veins. NKB did not affect vasoactive responsiveness of rat mesenteric arteries. CONCLUSION: We conclude from these observations that NKB is not the circulating factor associated with increased vascular resistance in PE.

Original language	English
Pages (from-to)	196-202
Number of pages	6
Journal	American Journal of Obstetrics and Gynecology
Volume	188
Issue number	1
DOIs	https://doi.org/10.1067/mob.2003.114
Publication status	Published - 1 Jan 2003

Keywords

Circulating factor
Human blood vessels
Preeclampsia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1067/mob.2003.114

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title = "Vasoactive effects of neurokinin B on human blood vessels",

abstract = "OBJECTIVES: Preeclampsia (PE) is a multisystem disease unique to human pregnancy. Abnormal placentation results in placental hypoperfusion leading to the secretion of a factor(s) by the placenta. Our aim was to investigate whether neurokinin B (NKB) is the circulating factor associated with PE. STUDY DESIGN: Vascular effects of NKB were assessed in blood vessels dissected from myometrial and omental biopsy specimens obtained at caesarean section from normal pregnant women (n = 26) or in mesenteric blood vessels obtained from nonpregnant female Wistar rats (n = 4). RESULTS: Incubation with NKB did not alter endothelial-dependent relaxation of omental or myometrial arteries. NKB produced a dose-dependent relaxation in preconstricted omental arteries and veins. NKB did not affect vasoactive responsiveness of rat mesenteric arteries. CONCLUSION: We conclude from these observations that NKB is not the circulating factor associated with increased vascular resistance in PE.",

keywords = "Circulating factor, Human blood vessels, Preeclampsia",

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year = "2003",

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doi = "10.1067/mob.2003.114",

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T1 - Vasoactive effects of neurokinin B on human blood vessels

AU - Wareing, Mark

AU - Bhatti, Hina

AU - O'Hara, Maureen

AU - Kenny, Louise

AU - Warren, Averil Y.

AU - Taggart, Michael J.

AU - Baker, Philip N.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - OBJECTIVES: Preeclampsia (PE) is a multisystem disease unique to human pregnancy. Abnormal placentation results in placental hypoperfusion leading to the secretion of a factor(s) by the placenta. Our aim was to investigate whether neurokinin B (NKB) is the circulating factor associated with PE. STUDY DESIGN: Vascular effects of NKB were assessed in blood vessels dissected from myometrial and omental biopsy specimens obtained at caesarean section from normal pregnant women (n = 26) or in mesenteric blood vessels obtained from nonpregnant female Wistar rats (n = 4). RESULTS: Incubation with NKB did not alter endothelial-dependent relaxation of omental or myometrial arteries. NKB produced a dose-dependent relaxation in preconstricted omental arteries and veins. NKB did not affect vasoactive responsiveness of rat mesenteric arteries. CONCLUSION: We conclude from these observations that NKB is not the circulating factor associated with increased vascular resistance in PE.

AB - OBJECTIVES: Preeclampsia (PE) is a multisystem disease unique to human pregnancy. Abnormal placentation results in placental hypoperfusion leading to the secretion of a factor(s) by the placenta. Our aim was to investigate whether neurokinin B (NKB) is the circulating factor associated with PE. STUDY DESIGN: Vascular effects of NKB were assessed in blood vessels dissected from myometrial and omental biopsy specimens obtained at caesarean section from normal pregnant women (n = 26) or in mesenteric blood vessels obtained from nonpregnant female Wistar rats (n = 4). RESULTS: Incubation with NKB did not alter endothelial-dependent relaxation of omental or myometrial arteries. NKB produced a dose-dependent relaxation in preconstricted omental arteries and veins. NKB did not affect vasoactive responsiveness of rat mesenteric arteries. CONCLUSION: We conclude from these observations that NKB is not the circulating factor associated with increased vascular resistance in PE.

KW - Circulating factor

KW - Human blood vessels

KW - Preeclampsia

U2 - 10.1067/mob.2003.114

DO - 10.1067/mob.2003.114

M3 - Article

VL - 188

SP - 196

EP - 202

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 1

ER -

Vasoactive effects of neurokinin B on human blood vessels

Abstract

Keywords

UN SDGs

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