Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF.

Nikolaus Jander; Willibald Hochholzer; Beat A Kaufmann; Edda Bahlmann; Eva Gerdts; Kurt Boman; John B Chambers; Christoph A Nienaber; Simon Ray; Anne Rossebo; Terje R Pedersen; Kristian Wachtell; Christa Gohlke-Bärwolf; Franz-Josef Neumann; Jan Minners

doi:10.1136/heartjnl-2014-305763

Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF.

Nikolaus Jander, Willibald Hochholzer, Beat A Kaufmann, Edda Bahlmann, Eva Gerdts, Kurt Boman, John B Chambers, Christoph A Nienaber, Simon Ray, Anne Rossebo, Terje R Pedersen, Kristian Wachtell, Christa Gohlke-Bärwolf, Franz-Josef Neumann, Jan Minners

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To evaluate the usefulness of velocity ratio (VR) in patients with low gradient severe aortic stenosis (LGSAS) and preserved EF. BACKGROUND: LGSAS despite preserved EF represents a clinically challenging entity. Reliance on mean pressure gradient (MPG) may underestimate stenosis severity as has been reported in the context of paradoxical low flow, LGSAS. On the other hand, grading of stenosis severity by aortic valve area (AVA) may overrate stenosis severity due to erroneous underestimation of LV outflow tract (LVOT) diameter, small body size or inconsistencies in cut-off values for severe stenosis. We hypothesised that VR may have conceptual advantages over MPG and AVA, predict clinical outcomes and thereby be useful in the management of patients with LGSAS. METHODS: Patients from the prospective Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study with an AVA

Original language	English
Journal	Heart (British Cardiac Society)
DOIs	https://doi.org/10.1136/heartjnl-2014-305763
Publication status	Published - 12 Sept 2014

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Jander, N., Hochholzer, W., Kaufmann, B. A., Bahlmann, E., Gerdts, E., Boman, K., Chambers, J. B., Nienaber, C. A., Ray, S., Rossebo, A., Pedersen, T. R., Wachtell, K., Gohlke-Bärwolf, C., Neumann, F.-J., & Minners, J. (2014). Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF. Heart (British Cardiac Society). https://doi.org/10.1136/heartjnl-2014-305763

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title = "Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF.",

abstract = "OBJECTIVE: To evaluate the usefulness of velocity ratio (VR) in patients with low gradient severe aortic stenosis (LGSAS) and preserved EF. BACKGROUND: LGSAS despite preserved EF represents a clinically challenging entity. Reliance on mean pressure gradient (MPG) may underestimate stenosis severity as has been reported in the context of paradoxical low flow, LGSAS. On the other hand, grading of stenosis severity by aortic valve area (AVA) may overrate stenosis severity due to erroneous underestimation of LV outflow tract (LVOT) diameter, small body size or inconsistencies in cut-off values for severe stenosis. We hypothesised that VR may have conceptual advantages over MPG and AVA, predict clinical outcomes and thereby be useful in the management of patients with LGSAS. METHODS: Patients from the prospective Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study with an AVA",

author = "Nikolaus Jander and Willibald Hochholzer and Kaufmann, {Beat A} and Edda Bahlmann and Eva Gerdts and Kurt Boman and Chambers, {John B} and Nienaber, {Christoph A} and Simon Ray and Anne Rossebo and Pedersen, {Terje R} and Kristian Wachtell and Christa Gohlke-B{\"a}rwolf and Franz-Josef Neumann and Jan Minners",

year = "2014",

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doi = "10.1136/heartjnl-2014-305763",

language = "English",

journal = "Heart (British Cardiac Society)",

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Jander, N, Hochholzer, W, Kaufmann, BA, Bahlmann, E, Gerdts, E, Boman, K, Chambers, JB, Nienaber, CA, Ray, S, Rossebo, A, Pedersen, TR, Wachtell, K, Gohlke-Bärwolf, C, Neumann, F-J & Minners, J 2014, 'Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF.', Heart (British Cardiac Society). https://doi.org/10.1136/heartjnl-2014-305763

TY - JOUR

T1 - Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF.

AU - Jander, Nikolaus

AU - Hochholzer, Willibald

AU - Kaufmann, Beat A

AU - Bahlmann, Edda

AU - Gerdts, Eva

AU - Boman, Kurt

AU - Chambers, John B

AU - Nienaber, Christoph A

AU - Ray, Simon

AU - Rossebo, Anne

AU - Pedersen, Terje R

AU - Wachtell, Kristian

AU - Gohlke-Bärwolf, Christa

AU - Neumann, Franz-Josef

AU - Minners, Jan

PY - 2014/9/12

Y1 - 2014/9/12

N2 - OBJECTIVE: To evaluate the usefulness of velocity ratio (VR) in patients with low gradient severe aortic stenosis (LGSAS) and preserved EF. BACKGROUND: LGSAS despite preserved EF represents a clinically challenging entity. Reliance on mean pressure gradient (MPG) may underestimate stenosis severity as has been reported in the context of paradoxical low flow, LGSAS. On the other hand, grading of stenosis severity by aortic valve area (AVA) may overrate stenosis severity due to erroneous underestimation of LV outflow tract (LVOT) diameter, small body size or inconsistencies in cut-off values for severe stenosis. We hypothesised that VR may have conceptual advantages over MPG and AVA, predict clinical outcomes and thereby be useful in the management of patients with LGSAS. METHODS: Patients from the prospective Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study with an AVA

AB - OBJECTIVE: To evaluate the usefulness of velocity ratio (VR) in patients with low gradient severe aortic stenosis (LGSAS) and preserved EF. BACKGROUND: LGSAS despite preserved EF represents a clinically challenging entity. Reliance on mean pressure gradient (MPG) may underestimate stenosis severity as has been reported in the context of paradoxical low flow, LGSAS. On the other hand, grading of stenosis severity by aortic valve area (AVA) may overrate stenosis severity due to erroneous underestimation of LV outflow tract (LVOT) diameter, small body size or inconsistencies in cut-off values for severe stenosis. We hypothesised that VR may have conceptual advantages over MPG and AVA, predict clinical outcomes and thereby be useful in the management of patients with LGSAS. METHODS: Patients from the prospective Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study with an AVA

U2 - 10.1136/heartjnl-2014-305763

DO - 10.1136/heartjnl-2014-305763

M3 - Article

C2 - 25217488

SN - 1468-201X

JO - Heart (British Cardiac Society)

JF - Heart (British Cardiac Society)

ER -

Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF.

Abstract

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