Vinculins interaction with talin is essential for mammary epithelial differentiation.

Pengbo Wang, Jian Wu, Amber Wood, Matthew Jones, Robert Pedley, Weiping Li, Robert Ross, Christoph Ballestrem, Andrew Gilmore, Charles Streuli

Research output: Contribution to journalArticlepeer-review


Vinculin is an essential component of cell adhesion complexes, where it regulates the strength and stability of adhesions. Whilst the role of vinculin in cell motility is well established, it remains unclear how vinculin contributes to other aspects of tissue function. Here we examine the role of vinculin in mammary epithelial cell phenotype. In these cells, correct adhesion to the extracellular matrix is essential for both the formation of polarised secretory acini and for the transcription of tissue-specific milk protein genes. We show that vinculin, through its interaction with talin, controls milk protein gene expression. However, vinculin is not required for the formation of polarised acini. This work reveals new roles for vinculin that are central to cellular differentiation, and for the ability of cells to interpret their extracellular microenvironment.
Original languageEnglish
Article number18400
JournalScientific Reports
Early online date5 Dec 2019
Publication statusPublished - 2020

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


Dive into the research topics of 'Vinculins interaction with talin is essential for mammary epithelial differentiation.'. Together they form a unique fingerprint.

Cite this