VIP receptors control excitability of suprachiasmatic nuclei neurones

Pavel Pakhotin; Anthony J. Harmar; Alexei Verkhratsky; Hugh Piggins

doi:10.1007/s00424-005-0003-z

VIP receptors control excitability of suprachiasmatic nuclei neurones

Pavel Pakhotin, Anthony J. Harmar, Alexei Verkhratsky, Hugh Piggins

Research output: Contribution to journal › Article › peer-review

Abstract

The role of vasoactive intestinal polypeptide (VIP) receptors on excitable properties of neurones in slices acutely prepared from the suprachiasmatic nuclei (SCN) of wild-type (WT) and VPAC2-receptor-deficient (Vipr2-/-) mice was studied under voltage clamp with the use of patch-clamp recording in the whole-cell configuration. The resting membrane potential in Vipr2-/- neurones was significantly hyperpolarised as compared to WT cells (-60±7 vs -72±6 mV, p

Original language	English
Pages (from-to)	7-15
Number of pages	8
Journal	Pflügers Archiv European Journal of Physiology
Volume	452
Issue number	1
DOIs	https://doi.org/10.1007/s00424-005-0003-z
Publication status	Published - Apr 2006

Keywords

Circadian
Mouse
Potassium currents
SCN
Sodium currents
VIP receptors

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10.1007/s00424-005-0003-z

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abstract = "The role of vasoactive intestinal polypeptide (VIP) receptors on excitable properties of neurones in slices acutely prepared from the suprachiasmatic nuclei (SCN) of wild-type (WT) and VPAC2-receptor-deficient (Vipr2-/-) mice was studied under voltage clamp with the use of patch-clamp recording in the whole-cell configuration. The resting membrane potential in Vipr2-/- neurones was significantly hyperpolarised as compared to WT cells (-60±7 vs -72±6 mV, p",

keywords = "Circadian, Mouse, Potassium currents, SCN, Sodium currents, VIP receptors",

author = "Pavel Pakhotin and Harmar, {Anthony J.} and Alexei Verkhratsky and Hugh Piggins",

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AU - Pakhotin, Pavel

AU - Harmar, Anthony J.

AU - Verkhratsky, Alexei

AU - Piggins, Hugh

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AB - The role of vasoactive intestinal polypeptide (VIP) receptors on excitable properties of neurones in slices acutely prepared from the suprachiasmatic nuclei (SCN) of wild-type (WT) and VPAC2-receptor-deficient (Vipr2-/-) mice was studied under voltage clamp with the use of patch-clamp recording in the whole-cell configuration. The resting membrane potential in Vipr2-/- neurones was significantly hyperpolarised as compared to WT cells (-60±7 vs -72±6 mV, p

KW - Circadian

KW - Mouse

KW - Potassium currents

KW - SCN

KW - Sodium currents

KW - VIP receptors

U2 - 10.1007/s00424-005-0003-z

DO - 10.1007/s00424-005-0003-z

M3 - Article

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EP - 15

JO - Pflügers Archiv European Journal of Physiology

JF - Pflügers Archiv European Journal of Physiology

IS - 1

ER -

VIP receptors control excitability of suprachiasmatic nuclei neurones

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Keywords

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