Virtual topological optimisation of scaffolds for rapid prototyping.

Henrique de Amorim Almeida, Paulo Jorge Da Silva bartolo

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Advanced additive techniques are now being developed to fabricate scaffolds with controlled architecture for tissue engineering. These techniques combine computer-aided design (CAD) with computer-aided manufacturing (CAM) tools to produce three-dimensional structures layer by layer in a multitude of materials. Actual prediction of the effective mechanical properties of scaffolds produced by additive technologies, is very important for tissue engineering applications. A novel computer based technique for scaffold design is topological optimisation. Topological optimisation is a form of "shape" optimisation, usually referred to as "layout" optimisation. The goal of topological optimisation is to find the best use of material for a body that is subjected to either a single load or a multiple load distribution. This paper proposes a topological optimisation scheme in order to obtain the ideal topological architectures of scaffolds, maximising its mechanical behaviour.
    Original languageEnglish
    JournalMedical engineering & physics
    Volume32
    Issue number7
    DOIs
    Publication statusPublished - Sept 2010

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