Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice

Elaine Bignell, Susana Negrete-Urtasun, Ana Maria Calcagno, Herbert N. Arst, Tom Rogers, Ken Haynes

    Research output: Contribution to journalArticlepeer-review

    Abstract

    While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47phox-/- mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent p-aminobenzoate auxotroph. This demonstrates that p47 phox-/- murine immunity contributes significantly to A. nidulans lethality. These data have wider implications for microbial virulence studies with p47phox-/- mice. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
    Original languageEnglish
    Pages (from-to)5204-5207
    Number of pages3
    JournalInfection and immunity
    Volume73
    Issue number8
    DOIs
    Publication statusPublished - Aug 2005

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