Abstract
While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47phox-/- mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent p-aminobenzoate auxotroph. This demonstrates that p47 phox-/- murine immunity contributes significantly to A. nidulans lethality. These data have wider implications for microbial virulence studies with p47phox-/- mice. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Original language | English |
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Pages (from-to) | 5204-5207 |
Number of pages | 3 |
Journal | Infection and immunity |
Volume | 73 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2005 |