Virus infections in immunocompromised patients: Their importance and their management

R. N P Sutton; R. F. Itzhaki; J. Christophers; J. Saldanha; A. Gannicliffe; H. Anderson

Virus infections in immunocompromised patients: Their importance and their management

R. N P Sutton, R. F. Itzhaki, J. Christophers, J. Saldanha, A. Gannicliffe, H. Anderson

Research output: Contribution to journal › Article › peer-review

Abstract

Opportunistic viral infections were investigated in 156 adult patients admitted over 1 year to a medical oncology service: 35% of the total group and 65% of those with acute leukaemia experienced viral infections, 79% of which were with viruses of the herpes group. Surprisingly few enteric viruses were recovered. Reactivation of herpes simplex virus in the brains of these immunosuppressed patients was suggested by the demonstration by nucleic acid hybridization of herpes simplex virus DNA sequences in neurones and endothelial cells in patients with evidence of past infection with virus. Acyclovir was effective in therapy and prophylaxis. Twenty-three strains from 7 patients were tested for sensitivity to this antiviral: in 3 instances clinical resistance was observed but the strains were fully sensitive in vitro, as were all other strains tested.

Original language	English
Pages (from-to)	100-105
Number of pages	5
Journal	Journal of the Royal Society of Medicine
Volume	78
Issue number	2
Publication status	Published - 1985

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title = "Virus infections in immunocompromised patients: Their importance and their management",

abstract = "Opportunistic viral infections were investigated in 156 adult patients admitted over 1 year to a medical oncology service: 35% of the total group and 65% of those with acute leukaemia experienced viral infections, 79% of which were with viruses of the herpes group. Surprisingly few enteric viruses were recovered. Reactivation of herpes simplex virus in the brains of these immunosuppressed patients was suggested by the demonstration by nucleic acid hybridization of herpes simplex virus DNA sequences in neurones and endothelial cells in patients with evidence of past infection with virus. Acyclovir was effective in therapy and prophylaxis. Twenty-three strains from 7 patients were tested for sensitivity to this antiviral: in 3 instances clinical resistance was observed but the strains were fully sensitive in vitro, as were all other strains tested.",

author = "Sutton, {R. N P} and Itzhaki, {R. F.} and J. Christophers and J. Saldanha and A. Gannicliffe and H. Anderson",

year = "1985",

language = "English",

volume = "78",

pages = "100--105",

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T1 - Virus infections in immunocompromised patients: Their importance and their management

AU - Sutton, R. N P

AU - Itzhaki, R. F.

AU - Christophers, J.

AU - Saldanha, J.

AU - Gannicliffe, A.

AU - Anderson, H.

PY - 1985

Y1 - 1985

N2 - Opportunistic viral infections were investigated in 156 adult patients admitted over 1 year to a medical oncology service: 35% of the total group and 65% of those with acute leukaemia experienced viral infections, 79% of which were with viruses of the herpes group. Surprisingly few enteric viruses were recovered. Reactivation of herpes simplex virus in the brains of these immunosuppressed patients was suggested by the demonstration by nucleic acid hybridization of herpes simplex virus DNA sequences in neurones and endothelial cells in patients with evidence of past infection with virus. Acyclovir was effective in therapy and prophylaxis. Twenty-three strains from 7 patients were tested for sensitivity to this antiviral: in 3 instances clinical resistance was observed but the strains were fully sensitive in vitro, as were all other strains tested.

AB - Opportunistic viral infections were investigated in 156 adult patients admitted over 1 year to a medical oncology service: 35% of the total group and 65% of those with acute leukaemia experienced viral infections, 79% of which were with viruses of the herpes group. Surprisingly few enteric viruses were recovered. Reactivation of herpes simplex virus in the brains of these immunosuppressed patients was suggested by the demonstration by nucleic acid hybridization of herpes simplex virus DNA sequences in neurones and endothelial cells in patients with evidence of past infection with virus. Acyclovir was effective in therapy and prophylaxis. Twenty-three strains from 7 patients were tested for sensitivity to this antiviral: in 3 instances clinical resistance was observed but the strains were fully sensitive in vitro, as were all other strains tested.

M3 - Article

C2 - 2983073

SN - 1758-1095

VL - 78

SP - 100

EP - 105

JO - Journal of the Royal Society of Medicine

JF - Journal of the Royal Society of Medicine

IS - 2

ER -

Virus infections in immunocompromised patients: Their importance and their management

Abstract

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